Sclerotherapic effects of different concentrations of lauromacrogol on endometrial cyst models in rats in two retention ways

Objective To compare the sclerotherapic effects of different concentrations of lauromacrogol on endometrial cyst models in rats in two ways: 10 minutes retention with extraction and retention without extraction. Methods Ninety SD rats after modeling were randomly divided into three groups: group A, 10 minutes retention with extraction; group B, retention without extraction; group C, normal saline. While both A and B group were randomly divided into four subgroups with different concentrations: 1%, 0.5%, 0.25%, and 0.125%. Seven days after treatment the cure rates and histopathological changes were observed. Results Cure rates in group A were 86.7%, 71.4%, 50% and 20%; in group B were 100%, 100%, 87.5% and 37.5%. In both A and B groups, the cure rates were not significantly different between 1%, 0.5% and 0.25% concentration subgroups (P>0.05), the cure rates of these subgroups in group B had statistical significance with 0.125% concentration subgroups and the saline control group(P 0.05), but between 0.5% and 0.25% concentration subgroups, it had statistical significance(P<0.05). Conclusions It will be conductive to enhancing the sclerotherapic effect if the lauromacrogol concentration remains above 0.25% and does not be extracted from the cyst models. Key words: Ultrasonography; Endometrial cyst; Sclerotherapy; Lauromacrogol