Cost-effectiveness of hysterosalpingography, laparoscopy, and Chlamydia antibody testing in subfertile couples

Ben W. Mol, B. W. Mol, J A Collins, John A. Collins, Fulco van der Veen, F. van der Veen, P M Bossuyt, Patrick M.M Bossuyt
Fertility and sterility · 2001 · vol. 75(3) , pp. 571–580 · doi:10.1016/s0015-0282(00)01748-9 · PMID:11239544 · W2050901763
Other OA: closed CC0 ⤵ 10 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-14 ⓘ

This study assessed the cost-effectiveness of hysterosalpingography, laparoscopy, and Chlamydia antibody testing for evaluating subfertility in couples.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To evaluate the cost-effectiveness analysis of hysterosalpingography (HSG), laparoscopy, and Chlamydia antibody testing (CAT) in subfertile couples. DESIGN: Cost-effectiveness analysis. SETTING: Decision analytic framework. PATIENT(S): Data of >2,000 subfertile couples in the Canadian Infertility Treatment Evaluation Study. Results of CA-125 measurement and CAT were simulated from baseline characteristics. INTERVENTION(S): Expectant management was considered to be the reference strategy (strategy 1). In strategy 2 and 3, IVF was offered either immediately or after 2.5 years. In strategy 4, the decision to offer or delay treatment was based on the couple's chance of spontaneous conception. Nine strategies incorporated combinations of CAT, CA-125 measurement, HSG, and laparoscopy. MAIN OUTCOME MEASURE(S): Expected live birth rates, expected number of IVF cycles, and expected total costs. RESULT(S): The strategy starting with CAT was the most cost-effective in couples whose 3-year chance of conception was >14%, whereas the strategy starting with HSG was the most cost-effective in couples with worse fertility prospects. CONCLUSION(S): The diagnostic work-up to detect tubal pathology in subfertile couples should start with CAT in couples with relatively good fertility prospects and immediate HSG in couples with relatively poor fertility prospects.

My notes (saved in your browser only)

MeSH descriptors

Antibodies, Bacterial Chlamydia Cost-Benefit Analysis Hysterosalpingography Infertility Laparoscopy Adult Antibodies, Bacterial CA-125 Antigen CA-125 Antigen Chlamydia Chlamydia Infections Chlamydia Infections Chlamydia Infections Fallopian Tube Diseases Fallopian Tube Diseases Fallopian Tube Diseases Female Fertilization in Vitro Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (26)

Cited by (8)

Source provenance

openalex
last seen: 2026-05-11T05:37:28.352103+00:00
pubmed
last seen: 2026-10-08T20:59:46.244316+00:00
License: CC0 · commercial use OK