Next-generation genomic signature highlights sustained AKT and estrogen receptor signaling as key mediators of resistance following phosphatidylinositol 3-kinase (PI3K) inhibition in patient-derived xenograft models with and without PIK3CA gene mutations

Whitfield B. Growdon, J. Alejandro Rauh‐Hain, R. Foster, Manoj Bhasin, Bo R. Rueda
In: Gynecologic Oncology · 2016 · vol. 141 , pp. 147 · doi:10.1016/j.ygyno.2016.04.383 · W2476482990
article OA: closed CC0
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This research utilized patient-derived xenograft models to demonstrate that sustained AKT and estrogen receptor signaling drive resistance to PI3K inhibition, regardless of the presence of PIK3CA gene mutations.

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