Expression of aminopeptidase N and neutral endopeptidase on the endometrial stromal cells in endometriosis and adenomyosis
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Endometrial stromal cells in endometriosis and adenomyosis express aminopeptidase N (CD13) and neutral endopeptidase (CD10), similar to normal endometrial stromal cells, suggesting their utility as diagnostic markers.
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Abstract
Indirect immunofluorescence staining revealed that endometrial stromal cells (ESC) in the ectopic endometrium of patients with endometriosis or adenomyosis expressed aminopeptidase N/cluster of differentiation (CD) 13 antigen and neutral endopeptidase/CD10 antigen, both of which are expressed on ESC in the normal endometrium throughout the menstrual cycle. Thus, ESC in the ectopic endometrium resembled ESC in the normal endometrium not only morphologically but also antigenically. Both peptidase antigens may be useful markers for the histological diagnosis of endometriosis and adenomyosis.
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- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
- pubmed
- last seen: 2026-05-13T22:11:44.647872+00:00
- unpaywall
- last seen: 2026-05-14T19:30:52.867331+00:00
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine