Effect of the selective estrogen receptor modulator raloxifene on explanted uterine growth in rats

D.K. Swisher, Robert M. Tague, David E. Seyler
In: Drug Development Research · 1995 · vol. 36(1) , pp. 43–45 · doi:10.1002/ddr.430360107 · W1972753146
Lab / animal OA: closed CC0 ⤵ 12 in-corpus citations
View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Raloxifene treatment significantly decreased uterine explant weight and volume in rats with an artificially created endometriosis-like state, also reducing the weight of the remaining uterine horn.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Abstract Raloxifene is a selective estrogen receptor modulator known to have antiestrogenic effects on uterine tissue. In this study, the effects of raloxifene on uterine explant growth were evaluated in rats. Rats were ovariectomized, implanted with an estradiol pellet, and an endometriosis‐like state was artificially created by suturing uterine explants near mesenteric blood vessels. Approximately 21 days after explant surgery, rats with confirmed uterine explant growth were given raloxifene orally at doses of 0 or 10 mg/kg/day for 7 or 14 days. After 7 days of raloxifene treatment, explant weight and volume were significantly decreased. Fourteen days of raloxifene treatment, also caused a decrease in explant weight and volume, though not statistically significant. In addition, raloxifene treatment caused weight of the remaining uterine horn to decrease. Histological examination of the explants confirmed the presence of endometrial tissue similar to that seen in the uterus. In this study, raloxifene suppressed explanted uterine growth in a rat model designed to mimic human endometriosis. © 1995 Wiley‐Liss, Inc.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (8)

Cited by (12)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK