Antinuclear antibodies in patients with endometriosis: A cross-sectional study in 94 patients

Vilas Boas L, Laura Vilas Boas, Carlos Bezerra Sobrinho, Bezerra Sobrinho C, Rahal D, Danilo Rahal, Augusto Capellari C, Cesar Augusto Capellari, Skare T, Thelma Skare, Renato Nisihara, NISIHARA R
Human immunology · 2021 · vol. 83(1) , pp. 70–73 · doi:10.1016/j.humimm.2021.10.001 · PMID:34686383 · W3207725205
Observational OA: closed CC0 ⤵ 5 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

This cross-sectional study investigated the prevalence of antinuclear antibodies in 94 patients diagnosed with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Markers of autoimmunity, such as autoantibodies, have been found in patients with endometriosis. These include the antinuclear antibodies (ANA). We aimed to evaluate the prevalence of ANA in a sample of patients with endometriosis and its possible clinical associations. Ninety-four patients with endometriosis and 91 controls were studied for ANA and extractable nuclear antigen (ENA; anti-Ro, anti-La, anti-Sm, and anti-RNP) profiles and anti-dsDNA. Epidemiological, clinical, and staging data in endometriosis were obtained. Patients with autoimmune disorders were excluded. Patients with endometriosis had a 21.2% prevalence of positive ANA vs. 5.4% in controls (P = 0.001). The ENA profile and anti-dsDNA were negative. Patients with positive ANA were more asymptomatic (P = 0.03) and had less dysmenorrhea. No associations with disease duration, patient age, or endometriosis stage were found. We found a high prevalence of positive ANA in patients with endometriosis. The presence of this autoantibody may be linked to a milder clinical expression of the disease.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Autoimmune Diseases Autoimmune Diseases Endometriosis Endometriosis Antibodies, Antinuclear Antibodies, Antinuclear Autoantibodies Autoantibodies Cross-Sectional Studies Cross-Sectional Studies Female Female Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (15)

Cited by (5)

Source provenance

europepmc
last seen: 2026-10-19T06:17:24.038039+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:32:46.934654+00:00
License: CC0 · commercial use OK