[Primary culture and morphologic observation of eutopic and ectopic endometrial cells from patients with endometriosis]

Chao-qin Yu, Chaoqin Yu, Yu CQ, Shu-Fang Shi, Shi SF, Yu-huan Liu, Liu YH, Rui-Xia Wang, Wang RX, Yan-Hua Song, Song YH, Jin Yu, Yu J
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine · 2006 · vol. 4(2) , pp. 189–193 · doi:10.3736/jcim20060216 · PMID:16529698 · W139356003
Lab / animal OA: closed CC0 ⤵ 6 in-corpus citations
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This study cultured eutopic and ectopic endometrial cells, observing distinct morphological and ultrastructural differences between endometriotic and normal endometrial glandular and stromal cells.

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Abstract

OBJECTIVE: To explore the method of primary culture for endometriotic cells and to find out the differences in morphological manifestations among endometriotic cells and eutopic endometrial cells sampled from patients with endometriosis and endometriosis-free women. METHODS: Endometriotic and eutopic endometrial cells were cultured by modified method of primary culture. The endometriotic cell types were observed and differentiated under optical and electron microscopes. RESULTS: The success rates for culture of eutopic endometrial cells from endometriosis-free women and patients with endometriosis were 91.67% and 93.75% respectively. The success rate for culture of endometriotic cells was 75.00%. The size of endometriotic glandular cells was similar to those of eutopic endometrial glandular cells from endometriosis-free women and patients with endometriosis. The chromatin was manifold and the nucleus was augmented in the endometriotic glandular cells. The endometriotic stromal cells were smaller than the eutopic endometrial stromal cells from endometriosis-free women and patients with endometriosis. Many tiny villi and protuberances on plasma membrane could be seen in the endometriotic stromal cells. CONCLUSION: The success rate for culture of endometriotic cells can be elevated through improving the method of primary culture. The ultrastructures of endometriotic glandular and stromal cells are obviously different from those of eutopic endometrial glandular and stromal cells from endometriosis-free women and patients with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cell Culture Techniques Endometriosis Endometrium Adult Adult Cell Culture Techniques Cell Culture Techniques Cells, Cultured Cells, Cultured Endometriosis Endometriosis Endometrium Endometrium Female Female Humans Humans Middle Aged Middle Aged

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References (9)

Cited by (6)

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