Diagnosis and methods of treatment of chronic endometritis in women of reproductive age

A. A. Sukhanov, Tyumen, Russian Federation, Г. Б. Дикке, I.I. Kukarskaya
In: Women's Health and Reproduction · 2024 · vol. 61(1) · doi:10.31550/2712-8598-2024-1-2-zhzir · W4392221748
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review examines diagnostic challenges and integrated treatment approaches for chronic endometritis, highlighting the roles of antibiotics, immunomodulation, and physiotherapy in improving fertility and pregnancy outcomes.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper is a narrative review that examines controversial issues in diagnosing and treating chronic endometritis (CE) and summarizes how CE may affect fertility and reproductive outcomes, drawing on both foreign and Russian literature. It highlights that immunohistochemistry for plasma cells (CD138) is considered the “gold standard,” but has limitations including lack of unified diagnostic cutoffs, potential misidentification due to similar-appearing cells, financial barriers, and insufficient standardization in clinical guidance; the review also notes that morphological studies can yield false-negative results. For treatment, the authors describe the absence of developed clinical guidelines and discuss a two-stage concept (elimination or activity reduction of the causative agent with local immune correction, followed by restoration of hemodynamics and receptor function), alongside discussion of natural antimicrobial peptides/cytokines and physiotherapy modalities. This paper is centrally about endometriosis—though its main focus is chronic endometritis and it does not explicitly discuss endometriosis, it is included in the corpus via keyword overlap with reproductive-fertility pathology.

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Abstract

Aim. To study the controversial issues of diagnosis and treatment of chronic endometritis (CE) and its impact on fertility, according to foreign and domestic authors. Key points. Although immunohistochemical study for plasma cells is considered the gold standard for diagnosing CE, it has limitations. The need to achieve consensus on the diagnostic criteria for cholecystitis was noted in order to exclude the influence of heterogeneity of studies on the assessment of treatment results. An integrated approach based on knowledge about the pathogenesis of CE facilitates the selection of adequate treatment. The positive role of antibacterial therapy in resolving CE is undoubted. In recent years, the need to restore immune defense in CE has been widely discussed. The importance of a complex of natural antimicrobial peptides and cytokines in restoring fertility and improving pregnancy outcomes has already been proven in several publications. Physiotherapeutic methods continue to be studied, and the most popular currently are cavitated solutions, peloids, electropulse and magnetic therapy. Conclusion. The diagnostic criteria for CE require a clear definition. Treatment of CE should include broad-spectrum antibiotic therapy, immunomodulatory therapy, and physiotherapy. Keywords: chronic endometritis, infertility, recurrent miscarriage, antibiotics, immunomodulators, peloid therapy, ultrasonic cavitation, interference therapy, magnetotherapy, laser therapy.

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Condition tags

infertilitydisambig:endometritis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (50)

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last seen: 2026-06-10T17:14:06.276822+00:00
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