Application of Physical Factors in the Chronic Endometritis Treatment: a Review

INTRODUCTION. Chronic inflammation in the uterine cavity is a fairly common problem in women of reproductive age, which negatively affects the state of the reproductive potential of the population. AIM. To present a scientific review of domestic and foreign literature covering modern methods and approaches of physical medicine used in the rehabilitation treatment of women with chronic endometritis. CONCLUSION. After analyzing the studied sources, we can conclude that the use of restorative medicine factors significantly expands the possibilities of treating chronic endometritis. Due to the use of complex or monotherapeutic techniques based on natural and preformed physical factors, it is possible to achieve outstanding results in restoring the morphofunctional potential of the endometrium. The main obstacle to the introduction of physical medicine approaches in practical healthcare is their low background, insufficient number of randomized studies that allows to use these methods as part of clinical recommendations. Further search and study of suitable non-drug regimens for chronic inflammation in the uterine cavity is needed, which will reduce the need for drug therapy.

pelvic inflammatory diseases, pelvis, chronic endometritis, non-drug treatment, physical factors FOR CITATION: Borisevich O.O., Fesyun A.D., Kotenko N.V. Application of Physical Factors in the Chronic Endometritis Treatment: a Review. Bulletin of Rehabilitation Medicine. 2023; 22(1): 110-116. https://doi.org/10.38025/2078-1962-2023-22-1-110-116 FOR CORRESPONDENCE: Olga O. Borisevich, E-mail: [email protected]

- Park H.J., Kim Y.S., Yoon T.K., Lee W.S. Chronic endometritis and infertility. Clinical and Experimental Reproductive Medicine. 2016; 43(4): 185-192. https://doi.org/10.5653/cerm.2016.43.4.185 - Kitaya K. Prevalence of chronic endometritis in recurrent miscarriages. Fertility and Sterility. 2011; 95(3): 1156-1158. https://doi.org/10.1016/j.fertn-stert.2010.09.061 - Kasius J.C., Fatemi H.M., Bourgain C., Sie-Go D.M., Eijkemans R.J., Fauser B.C., Devroey P., Broekmans F.J. The impact of chronic endometritis on reproductive outcome. Fertility and Sterility. 2011;96(6):1451–1456. https://doi.org/10.1016/j.fertnstert.2011.09.039 - Smith M., Hagerty K.A., Skipper B., Bocklage T. Chronic endometritis: a combined histopathologic and clinical review of cases from 2002 to 2007. International Journal of Gynecological Pathology: Official Journal of the International Society of Gynecological Pathologists. 2010; 29(1): 44-50. https://doi.org/10.1097/PGP.0b013e3181ae81bb - Kimura F., Takebayashi A., Ishida M., Nakamura A., Kitazawa J., Morimune A., Hirata K., Takahashi A., Tsuji S., Takashima A., Amano T., Tsuji S., Ono T., Kaku S., Kasahara K., Moritani S., Kushima R., Murakami T. Review: Chronic endometritis and its effect on reproduction. The Journal of Obstetrics and Gynaecology Research. 2019; 45(5): 951-960. https://doi.org/10.1111/jog.13937 - Romero R., Espinoza J., Mazor M. Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertility and Sterility. 2004; 82(4): 799-804. https://doi.org/10.1016/j.fertnstert.2004.05.076 - Zolghadri J., Momtahan M., Aminian K., Ghaffarpasand F., Tavana, Z. The value of hysteroscopy in diagnosis of chronic endometritis in patients with unexplained recurrent spontaneous abortion. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2011; 155(2): 217-220. https://doi.org/10.1016/j.ejogrb.2010.12.010 - Moreno I., Codoñer F. M., Vilella F., Valbuena D., Martinez-Blanch J.F., Jimenez-Almazán J., Alonso R., Alamá P., Remohí J., Pellicer A., Ramon D., Simon C. Evidence that the endometrial microbiota has an effect on implantation success or failure. American Journal of Obstetrics and Gynecology. 2016; 215(6): 684-703. https://doi.org/10.1016/j.ajog.2016.09.075 - Gushchina N.V., Kulchitskaya D.B., Kotenko N.V., Konchugova T.V. The сlinical experience of the application of local air cryotherapy in the treatment of patients with chronic endometritis. Physiotherapist. 2019; (2):18-22 (In Russ.). - Tsyganova T.N., Kulchitskaya D.B., Konchugova T.V. Effectiveness of interval hypoxic training in gynecology. Journal of New Medical Technologies. 2018; 25(4): 71-76 (In Russ.). - Konchugova T.V., Kotenko N.V., Borisevich O.O., Kulchitskaya D.B., Gushchina N.V. Scientific rationale for the use of natural and preformed physical factors in the treatment of patients with inflammatory gynecological diseases. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury. 2022; 99(3-2): 104-105 (In Russ.). - Kulchitskaya D.B., Fesyun A.D., Gushchina N.V., Kotenko N.V., Borisevich O.O., Nesterova E.V. Modern aspects of the use of methods of sanatorium treatment in patients with inflammatory diseases of the pelvic organs. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury. 2022; 99(3-2): 117-118 (In Russ.). - Kotenko N.V., Borisevich O.O. Possibilities of using natural and preformed physical factors in preconception preparation of women with chronic inflammatory diseases of the uterine appendages: a scientific review. V sbornike: Arbatskie chteniya. Sbornik nauchnyh trudov. 2021: 27-36. https://doi.org/10.38006/907345-95-9.2021.27.36 (In Russ.). - Lebedeva O.D., Knyazeva T.A., Bokova I.A., Yakovlev M.Yu., Nikiforova T.I., Lebedev G.A., Usmonzoda D.U. The use of new diagnostic and therapeutic non-drug technologies in rehabilitation of patients with common NCDS. Physiotherapist. 2017; (1):10-16 (In Russ.). - Arslanyan K.N., Malanova T.B., Strugatsky V.M. Physiotherapy in the practice of an obstetrician-gynecologist: clinical aspects and formulation. M. MEDpress-inform. 2013: 248 p. (In Russ.). - Ponomarenko G.N., Kondrina E.F. Physical methods of pre-conceptional endometrium preparation in the frame of assistant reproduction programs. Physiotherapist. 2012; (8): 049-054. (In Russ.). - Shishkanova O.L., Silant’eva E.S., Serov V.N., Burlev V.A. Hemodynamic aspects of pulsed electrotherapy in patients with chronic endometritis. Journal of the Russian Society of Obstetricians and Gynecologists. 2006; (3): 29-30 (In Russ.). - Silant’eva E.S. Immunohistochemical substantiation of the defibrosing effect of electrotherapy. Allergology and Immunology. 2006; 7(1): 66 p. (In Russ.). - Rachin A.P., Sharov M.N., Averchenkova A.A. et al. Chronic pain: from pathogenesis to innovative treatment. RMJ. 2017; (9): 625-631. (In Russ.). - Рlyasunova М.Р., Chlybova S.V., Feoktistov A.A., Shardakov V.I., Effects of combined physiotherapy in chronic endometritis: dynamics of inflammatory activity, Medical Immunology. 2014; 16(6): 587-592 (In Russ.). - Volkova E.Yu., Silant’eva E.S., Serov V.N., Korneeva I.E., Sokolova Yu.Yu. Impact of physiotherapy on uterine hemodynamics in women with reproductive dysfunction and thin endometrium. Russian Bulletin of Obstetrician-Gynecologist. 2012;12(3):50-54. (In Russ.). - Martynov S. A. potentialities of electrotherapy in the preparation of patients with chronic endometritis for assisted procreation (in-vitro fertilization) programs. Obstetrics and Gynecology. 2007; (1): 44-48 (In Russ.). - Skoropatskaya O.A., Yavorskaya S.D., Fadeeva N.I. Impact of assessment to an ultrasonic and some of immune-histochemical parameters of a combined two-stage treatment of chronic endometritis of infertile patients with the prolonged course of amplipulsetherapy. Mother and Baby in Kuzbass. 2018; (3):23-26. (In Russ.). - Radzinskiy V.E., Petrov Y.A., Polina M.L. The clinical effectiveness of impulse electrotherapy in the complex treatment of patients with chronic endometritis. Kazan Medical Journal. 2012; (1): 72-76 (In Russ.). - Gorodetskaya O.S., Chandra-D’mello R., Grechkanov G.O. the correction of morpho-functional indices of endometrium under the influence of general magnetotherapy of female patients with chronic endometritis. Medicinskij al’manah. 2011;19(6): 129-131 (In Russ.). - Samorukov A.E., Budylin S.P., Eremushkin M.A., Kotenko N.V., Gusarova S.A Manual therapy in treatment of chronic infl ammatory diseases of female reproductive system. V sbornike: Arbatskie chteniya. Sbornik nauchnyh trudov. 2020: 85-90 (In Russ.). - Ghaderi F., Bastani P., Hajebrahimi S., Jafarabadi M.A., Berghmans B. Pelvic floor rehabilitation in the treatment of women with dyspareunia: a randomized controlled clinical trial. International Urogynecology Journal. 2019; 30(11): 1849-1855. https://doi.org/10.1007/s00192-019-04019-3 - Samorukov A.E., Kotenko N.V., Borisevich O.O., Tarasova L.Yu. Sposob manual’noj korrekcii narushenij mikrocirkulyacii organov malogo taza u zhenshchin s hronicheskimi vospalitel’nymi zabolevaniyami matki i pridatkov. Patent № 2740264. Zayavka № 2020115769 dated May 13, 2020. (In Russ.). - Silant’eva E.S., Plyasunova M.P., Khlybova S.V., Feoktistov A.A., Shardakov V.I. Immunohistochemical substantiation of the defibrosing effect of electrotherapy. Allergology and Immunology. 2006; 7(1): 66 p. (In Russ.). - Dicke G.B. Increasing the effectiveness of the treatment of women with impaired reproductive function when using therapeutic mud from the Dead Sea. Obstetrics and Gynecology. 2015; (12): 31-38 (In Russ.). - Beer A.M., Fetaj S., Lange U. Peloidtherapie. Ein Überblick zur Empirie und Evidenz am Beispiel der Heiltorftherapie [Peloid therapy. An overview of the empirical status and evidence of mud therapy]. Zeitschrift für Rheumatologie. 2013; 72(6): 581-589. https://doi.org/10.1007/s00393-013-1144-7 - Beer A.M., Kovarik R., Münstermann M. Vaginale Moortherapie bei chronischer Salpingitis [Vaginal peat therapy for chronic salpingitis]. Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin. 1994; (4): 110-2. - Belokrinitskaya T. E, Frolova N. I., Glotova E. Yu. Effectiveness of intravaginal pelotherapy with dead sea mud in women with infertility. Obstetrics and Gynecology. 2014; (7): 68-73 (In Russ.). - Badalov N.G., Krikorova S.A. Mud therapy: theory, practice, problems and development prospects. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury. 2012; (3)): 50-4 (In Russ.). - Habek D., Cerovac A., Kamerić L., Nevačinović E., Šerak, A. Balneogynaecology in the 21st century: increasingly recommended primary and complementary treatment of chronic gynaecological diseases. Medicinski Glasnik. 2021; 18(1): 1-6. https://doi.org/10.17392/1263-21 - Bromirska D. Wpływ hipertermicznego i izotermicznego zabiegu borowinowego czynność hormonalna prawidłowego i niewydolnego ciałka zółtego u kobiet [Effect of hyperthermic and isothermic mud application on hormonal function of normal and insufficient corpus luteum in women]. Annales Academiae Medicae Stetinensis. 1993; (39): 133-146. - Vashkevich I.V., Kira E.F. Influence of pelotherapy on the microbiocenosis of the vagina of women suffering from various forms of infertility. Bulletin of Pirogov National Medical & Surgical Center. 2014; 9(1): 68-71 (In Russ.). - Kuzmina M.A. Resort factors in the system of rehabilitation treatment of patients with chronic inflammatory diseases of the pelvic organs, complicated by pelvic pain syndrome. Journal of the Russian Society of Obstetricians and Gynecologists. 2010; (2): 14-20 (In Russ.). - Bender T. et al. Evidence-based hydro- and balneotherapy in Hungary-a systematic review and meta-analysis. International Journal of Biometeorology. 2014; 58(3): 311-323. - Zámbó L., Dékány M., Bender T. The efficacy of alum-containing ferrous thermal water in the management of chronic inflammatory gynaecological disorders-A randomized controlled study. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2008; 140(2): 252-257. - Odabasi, E., Turan, M. The importance of body core temperature evaluation in balneotherapy. International Journal of Biometeorology. 2022; (66): 25-33. https://doi.org/10.1007/s00484-021-02201-1 - Barashkov G.N., Kotenko N.V., Gigineishvili G.R., Lanberg O.A. Hydrodynamic phytoaromatic baths and peloidotherapy in women during menopausal transition period. Bulletin of Rehabilitation Medicine. 2019; 94(6): 17-21 (In Russ.). - Chen P., Chen P., Guo Y., Fang C., Li T. Interaction Between Chronic Endometritis Caused Endometrial Microbiota Disorder and Endometrial Immune Environment Change in Recurrent Implantation Failure. Frontiers in Immunology. 2021; (12): 748447. https://doi.org/10.3389/fimmu.2021.748447 - Wang J., Li Z., Ma X., Du L., Jia Z., Cui X., Yu L., Yang J., Xiao L., Zhang B., Fan H., Zhao F. Translocation of vaginal microbiota is involved in impairment and protection of uterine health. Nature Communications. 2021; 12(1): 4191. https://doi.org/10.1038/s41467-021-24516-8 - Zhang Y., Yang H., Lin L., Yang W., Xiong G., Gao G. The relationship between pelvic floor functions and vaginal microbiota in 6-8 weeks postpartum women. Frontiers in Microbiology. 2022; (13): 975406. https://doi.org/10.3389/fmicb.2022.975406 - Li W., Hu Q., Zhang Z., Shen F., Xie Z. Effect of different electrical stimulation protocols for pelvic floor rehabilitation of postpartum women with extremely weak muscle strength: Randomized control trial. Medicine. 2020; 99(17): e19863. https://doi.org/10.1097/MD.0000000000019863 - Yang S., Sang W., Feng J. et al. The effect of rehabilitation exercises combined with direct vagina low voltage low frequency electric stimulation on pelvic nerve electrophysiology and tissue function in primiparous women: A randomised controlled trial. Journal of Clinical Nursing. 2017; 26(23-24): 4537-4547. https://doi.org/10.1111/jocn.13790 - Silantyeva E., Zarkovic D., Astafeva E. et al. A Comparative Study on the Effects of High-Intensity Focused Electromagnetic Technology and Electrostimulation for the Treatment of Pelvic Floor Muscles and Urinary Incontinence in Parous Women: Analysis of Posttreatment Data. Female Pelvic Medicine & Reconstructive Surgery. 2021; 27(4): 269-273. https://doi.org/10.1097/SPV.0000000000000807 - Stanton A.M., Kirakosian N. The Role of Biofeedback in the Treatment of Sexual Dysfunction. Current Sexual Health Reports. 2020; (12): 49-55. https://doi.org/10.1007/s11930-020-00257-5 The content is available under the Creative Commons Attribution 4.0 License. © This is an open article under the CC BY 4.0 license. Published by the National Medical Research Center for Rehabilitation and Balneology.