Random genetic drift determines the level of mutant mtDNA in human primary oocytes.

Brown DT; Samuels DC; Michael EM; Turnbull DM; Chinnery PF

doi:10.1086/318190

Random genetic drift determines the level of mutant mtDNA in human primary oocytes.

Brown DT, Samuels DC, Michael EM, Turnbull DM, Chinnery PF

American journal of human genetics · 2001 · doi:10.1086/318190 · PMID:11133360 · PMC1235288

OA: closed

📄 Open PDF View on PubMed View at publisher

Abstract

We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes.

My notes (saved in your browser only)

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

europepmc: last seen: 2026-07-13T06:13:37.491660+00:00