Samuels DC

IntroductionChronic overlapping pain conditions (COPCs) are a group of pain conditions that often co-occur and present with challenging nociplastic pain. Individuals with COPCs describe clinician skepticism and prolonged diagnosis, leading …

We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that de…