Causes of ovarian reserve reduction in endometrioid ovarian cysts

K.A. Bugerenko, Kirill V. Larin, L. N. Shcherbakova, А.Е. Бугеренко, Elena V. Proskurnina, О.Б. Панина
In: Voprosy ginekologii, akušerstva i perinatologii · 2018 · vol. 17(4) , pp. 25–30 · doi:10.20953/1726-1678-2018-4-25-30 · W2899739589
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Ovarian tissue adjacent to endometrioid cysts showed reduced radical-producing capability after NADH stimulation, suggesting antioxidant defense exhaustion contributes to ovarian reserve reduction.

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This study examined whether local oxidative stress contributes to ovarian reserve reduction in patients with endometrioid ovarian cysts by comparing radical-producing activity in ovarian tissue adjacent to the cyst versus control tissue from patients with benign ovarian tumors or PCOS. Using chemiluminescence to assess active oxygen formation, the authors found no excessive radical anion production in either group without stimulation, but NADH stimulation significantly increased chemiluminescence intensity in controls. In contrast, tissue adjacent to endometrioid cysts showed a significantly lower radical-producing response to NADH, which the authors interpreted as possible exhaustion of antioxidant defenses, particularly involving cells associated with NADH-dependent cytochrome-b5 reductase. This paper is centrally about endometriosis — it investigates oxidative stress mechanisms linked to ovarian reserve reduction in endometrioid ovarian cysts (endometrioma).

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Gynecology, Obstetrics and Perinatology - Gynecology, Obstetrics and Perinatology - 2018 volume 17 issue 4 Causes of ovarian reserve reduction in endometrioid ovarian cysts Authors / Institutions K.A.Bugerenko / K.V.Larin / Liya N. Shcherbakova / Andrey E. Bugerenko / Elena V. Proskurnina / Olga B. Panina / The objective. To study the role of local oxidative stress in reduction of ovarian reserve in patients with endometrioid ovarian cysts. Patients and methods. The treatment group comprised 16 patients with endometrioid cysts, the control group – 16 patients with benign ovarian tumours or PCOS. Results. In the absence of a stimulus, an equal radical-producing activity of ovarian tissue was recorded, assessed with the help of chemiluminescence, in the treatment and control groups, which is indicative of the absence of excessive production of radical anions directly in ovarian stroma with an endometrioid cyst. Addition of NADH resulted in a significant increase of the intensity of chemiluminescence (14.05 ± 4.01 imp/s) in patients of the control group. In patients with endometrioid cysts, the radical-producing capability of tissue adjacent to the endometrioid cyst in response to the stimulus was significantly lower (1.71 ± 0.02 imp/s), which might be indicative that the cause of ovarian lesion in endometrioid cysts is exhaustion of antioxidant defence due to local oxidative stress. Conclusion. One of the causes of ovarian reserve reduction of patients with endometrioid cysts is exhaustion of antioxidant defence of cells associated with NADH-dependent cytochrome-b5 reductase. Key words: active oxygen forms, ovarian reserve, oxidative stress, chemiluminescence, endometrioma. For citation: Bugerenko K.A., Larin K.V., Shcherbakova L.N., Bugerenko A.Ye., Proskurnina Ye.V., Panina O.B. Causes of ovarian reserve reduction in endometrioid ovarian cysts. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2018; 17(4): 25–30. (In Russian). DOI: 10.20953/1726-1678-2018-4-25-30 Patients and methods. The treatment group comprised 16 patients with endometrioid cysts, the control group – 16 patients with benign ovarian tumours or PCOS. Results. In the absence of a stimulus, an equal radical-producing activity of ovarian tissue was recorded, assessed with the help of chemiluminescence, in the treatment and control groups, which is indicative of the absence of excessive production of radical anions directly in ovarian stroma with an endometrioid cyst. Addition of NADH resulted in a significant increase of the intensity of chemiluminescence (14.05 ± 4.01 imp/s) in patients of the control group. In patients with endometrioid cysts, the radical-producing capability of tissue adjacent to the endometrioid cyst in response to the stimulus was significantly lower (1.71 ± 0.02 imp/s), which might be indicative that the cause of ovarian lesion in endometrioid cysts is exhaustion of antioxidant defence due to local oxidative stress. Conclusion. One of the causes of ovarian reserve reduction of patients with endometrioid cysts is exhaustion of antioxidant defence of cells associated with NADH-dependent cytochrome-b5 reductase. Key words: active oxygen forms, ovarian reserve, oxidative stress, chemiluminescence, endometrioma. For citation: Bugerenko K.A., Larin K.V., Shcherbakova L.N., Bugerenko A.Ye., Proskurnina Ye.V., Panina O.B. Causes of ovarian reserve reduction in endometrioid ovarian cysts. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2018; 17(4): 25–30. (In Russian). DOI: 10.20953/1726-1678-2018-4-25-30

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