Serum CA 125 antigen levels and disease severity in patients with endometriosis

Moloney MD, M D Moloney, Moloney, Thornton JG, J G Thornton, Jim Thornton, E H Cooper, Cooper Eh
Obstetrics and gynecology · 1989 · vol. 73(5 Pt 1) , pp. 767–9 · PMID:2704505 · W2395839036
Observational OA: closed CC0 ⤵ 9 in-corpus citations
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This study found a positive correlation between serum CA 125 levels and endometriosis severity in 52 patients, suggesting CA 125 may be useful for monitoring disease progress after excluding malignancy.

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Abstract

We wished to test whether there was a relationship between CA 125 levels and the severity of endometriosis that would allow CA 125 to be used to monitor disease progression. CA 125 levels were measured in 52 women with laparoscopically staged endometriosis and in eight women with normal pelvic findings at laparoscopy. There was a positive correlation (r = 0.63; P less than .0001) between disease severity and CA 125 levels. CA 125 was also elevated, compared with women with a normal pelvis, in patients with mild and moderate disease. There was no relationship between CA 125 levels and the day of the menstrual cycle. These results suggest that after malignancy has been excluded, CA 125 levels may offer a useful method of monitoring disease progress.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Endometriosis Antigens, Tumor-Associated, Carbohydrate Antigens, Tumor-Associated, Carbohydrate Endometriosis Endometriosis Endometriosis Female Female Humans Humans Menstrual Cycle Menstrual Cycle Neoplasm Staging Neoplasm Staging

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (9)

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License: CC0 · commercial use OK