[Expression of vascular endothelial growth factor (VEGF) in uterine tissues as one of the mechanisms of algogenezis in adenomyosis, associated with chronic pelvic pain].

V E Radzinskiy, Mekan R. Orazov, M R Orazov, O M Nosenko, О. М. Носенко
Patologicheskaia fiziologiia i eksperimental'naia terapiia · 2017 · vol. 60(1) , pp. 32–5 · PMID:29215242 · W3025834139
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Abstract

Methods. For morphological studies it were using fragments of walls 60 uterus, received after hysterectomy in patients with pelvic pain on a background of diffuse adenomyosis II-III degree, and 30 uterus of women with painless form of adenomyosis. Expression of vascular endothelial growth factor (VEGF) was measured in endometrial and myometrial tissues using immunohistochemistry. The results showed a significantly higher expression of VEGF in patients with adenomyosis pain phenotype compared to the same in women with silent form in the epithelial cells of ectopic endometrium (14,7 ± 1,6 vs. 10,7 ± 1,6%, p<0,01) in the smooth muscle cells of the myometrium (12,6 ± 1,4 vs. 9,6 ± 1,2%, p<0,01), in the stromal cells of the myometrium (10,1 ± 1,9 vs. 7,4 ± 1,8%, p <0,01).

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Condition tags

chronic_pelvic_painadenomyosis

MeSH descriptors

Adenomyosis Chronic Pain Gene Expression Regulation Myometrium Pelvic Pain Vascular Endothelial Growth Factor A Adenomyosis Adenomyosis Adult Chronic Pain Chronic Pain Female Humans Myometrium Myometrium Pelvic Pain Pelvic Pain Vascular Endothelial Growth Factor A

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