Serum concentrations of neuropilin-1 in women with endometriosis

Monika Barberić, Monika Barberic, Dinka Pavicic Baldani, Dinka Pavičić Baldani, Dunja Rogić, Dunja Rogic, Sasa Kralik, Saša Kralik
Scandinavian journal of clinical and laboratory investigation · 2020 · vol. 80(4) , pp. 271–276 · doi:10.1080/00365513.2020.1728785 · PMID:32069143 · W3008092280
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This study found significantly higher serum neuropilin-1 concentrations in women with endometriosis compared to healthy controls, indicating its potential as a non-invasive diagnostic marker.

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Abstract

Objective of this work is to investigate, for the first time, serum concentration of neuropilin-1 (NRP-1), aiming to evaluate its diagnostic performance in endometriosis and usability as a potential non-invasive serum marker of endometriosis. Two hundred women were treated laparoscopically. After laparoscopic surgery women were divided into two groups: 120 women diagnosed with endometriosis and 80 healthy women (control group). Blood samples were taken from all women undergoing laparoscopy half an hour before the induction of anesthesia, for the purpose of collection of serum. The level of NRP-1 in serum was assayed by a standardised sandwich enzyme-linked immunosorbent assay. Differences between endometriosis and healthy control group in NRP-1 levels were significant. All values were significantly and several times higher in patients group, p < .001. After receiver operating characteristic analysis, the area under curve was 0.97 (95% confidence interval: 0.941 to 0.989, p < .0001) at 11 µg/L cut-off level for NRP-1. Preliminary threshold values for NRP-1 in serum were assumed to serve as diagnostic parameters with sensitivity of 99.3% and specificity of 97.8%. Serum concentration of NRP-1 can be considered as a potentially good laboratory diagnostic, non-invasive marker for endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Neuropilin-1 Adolescent Adult Biomarkers Biomarkers Case-Control Studies Disease Progression Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Enzyme-Linked Immunosorbent Assay Female Gene Expression Humans Neuropilin-1

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