Risk factors for irreversible unilateral loss of renal function in patients with deep endometriosis

María-Angeles Martínez-Zamora, Maria Ángeles Martínez‐Zamora, Eduard Mensión, Judith Martínez-Egea, Lluis Peri, Lluís Peri, A. Franco, Agustín Franco, Meritxell Gracia, Meritxell Gràcia, Cristina Ros, Mariona Rius, Francisco Carmona
Scientific reports · 2023 · vol. 13(1) , pp. 11940 · doi:10.1038/s41598-023-38728-z · PMID:37488122 · W4385213956
article OA: gold CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study identified infertility, asymptomatic presentation, intestinal DE, torus uterinus/uterosacral ligament DE, and a negative sliding sign as risk factors for irreversible unilateral renal function loss in deep endometriosis patients.

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Abstract

Deep endometriosis (DE) can be more aggressive than other types of endometriosis, and may even lead to irreversible severe complications such as complete unilateral loss of renal function. We aimed to describe the clinical and radiologic characteristics of DE patients diagnosed with irreversible unilateral loss of renal function due to unilateral ureteral stenosis and evaluate risk factors for developing this loss. This retrospective cohort study included 436 patients who underwent laparoscopic DE surgery. We evaluated two groups of patients according to preserved (Non-Renal Loss Group; n = 421) or irreversible unilateral damaged renal function (Renal Loss Group; n = 15). Preoperative epidemiologic variables, clinical characteristics, radiologic findings and surgical treatments of all the patients were collected. The Renal Loss Group had a higher infertility rate and a higher proportion of asymptomatic patients. The following radiological variables showed statistically significant differences between the two groups: mean endometrioma diameter, the presence of intestinal DE and negative sliding sign. Multivariate analysis showed that infertility, being asymptomatic, having intestinal DE or torus uterinus/uterosacral ligament DE and a negative sliding sign significantly increased the risk of loss of renal function. Therefore, among patients with these clinical and/or radiological variables, severe urinary tract obstruction should be specifically ruled out.

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Condition tags

mesh:D004715endometriosisendometriomainfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Laparoscopy Laparoscopy Laparoscopy Laparoscopy Laparoscopy Ureteral Obstruction Ureteral Obstruction Ureteral Obstruction Ureteral Obstruction Ureteral Obstruction Ureteral Obstruction Female Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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