Celiac disease and endometriosis: what is the nexus?
This paper reviews the potential link between celiac disease and endometriosis, exploring immunological factors like interleukin-18 and interferon-gamma.
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This short article reviews evidence for an immunologic and epidemiologic “nexus” between celiac disease and endometriosis, focusing on shared immune pathways discussed across referenced studies. It highlights reports of increased endometriosis risk among women with celiac disease and summarizes additional work linking endometriosis to immune mediators such as IL-18 and interferon-γ, alongside broader associations between endometriosis and autoimmunity. A key limitation is that the piece is not an original study and does not provide new analyses, relying on heterogeneous findings from prior papers with varying populations and designs. Relevance to endometriosis: it explicitly centers on endometriosis risk in women with celiac disease (e.g., citing Stephansson et al., 2011) while also discussing immune markers like IL-18 in the endometriosis/adenomyosis literature. This paper is centrally about endometriosis — it addresses the proposed immunologic and epidemiologic links between endometriosis and celiac disease.
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