Effect of low-dose aspirin therapy on implantation rate in women undergoing in-vitro fertilization cycles

Ashraf Moini, Fatemeh Zafarani, Sedigheh Haddadian, Jila Ahmadi, Hooman Honar, Kiarash Riazi
In: Saudi Medical Journal · 2007 · vol. 28(5) , pp. 732–736 · doi:10.15537/1658-3175.3897 · PMID:17457441 · W1489043530
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Low-dose aspirin in IVF cycles did not improve implantation and pregnancy rates, although it did reduce OHSS occurrence.

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This randomized study investigated whether adding low-dose aspirin (100 mg daily) to standard IVF “long protocol” affects ovarian response, implantation rate, and pregnancy outcomes in 145 unselected infertile women (mean age 29.6 years) undergoing IVF at Royan Institute (Apr 2002–Jan 2004). Aspirin or placebo was started on day 21 of the preceding menstrual cycle and continued until menstruation or a negative pregnancy test, with continuation to 12 weeks of pregnancy if pregnant. Compared with placebo, the aspirin group showed a lower number of follicles reaching ≥15 mm and a lower OHSS occurrence, but there were no statistically significant differences in other measured outcomes, including implantation and pregnancy rates. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

OBJECTIVE: To determine the effect of low-dose aspirin on ovarian response, implantation and pregnancy rates in patients undergoing in-vitro fertilization (IVF) cycles. METHODS: We performed a randomized analysis of 145 infertile women with a mean+/-SD age of 29.6 +/- 4.47 years who underwent cycles of IVF. Patients received 100 mg of aspirin (n=72) or placebo (n=73) daily. This study was conducted in Royan Institute, Tehran, Iran from April 2002 to January 2004. Aspirin was started on the 21st of their preceding menstrual cycle and it was continued until menstruation or a negative pregnancy test. Pregnant women received the medication until 12 weeks of pregnancy. The main outcome measures were number of follicles >or=15 mm, number of oocytes retrieved, serum E2 levels, cancellation rate, Ovarian Hyperstimulation Syndrome (OHSS) occurrence, number of embryos transferred, and implantation and pregnancy rates. RESULTS: There were statistically significant differences between the treatment group and the control group in the number of follicles (7.4 +/- 4.1 versus 9.0 +/- 4.8) and OHSS occurrence (5.6% versus 23.3%) but not in the other measures. CONCLUSION: The addition of aspirin low dose (100 mg/daily) to the standard long protocol for oocyte retrieval did not improve implantation and pregnancy rates in unselected patients undergoing IVF cycles.
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Authors - Ashraf Moini, Associated Professor of Obstetric and Gynecology, Department of Endocrinology and Female Infertility, Royan Institute, PO Box 19395-4644, No 36, Simin Alley, Asef Cross, Zaferanieh, Tehran, Iran. Tel. +98 (21) 22413790. Fax. +98 (21) 22409314. E-mail: a_moini{at}royaninstitute.org - Fatemeh Zafarani, Associated Professor of Obstetric and Gynecology, Department of Endocrinology and Female Infertility, Royan Institute, PO Box 19395-4644, No 36, Simin Alley, Asef Cross, Zaferanieh, Tehran, Iran. Tel. +98 (21) 22413790. Fax. +98 (21) 22409314. E-mail: a_moini{at}royaninstitute.org - Sedigheh Haddadian, Associated Professor of Obstetric and Gynecology, Department of Endocrinology and Female Infertility, Royan Institute, PO Box 19395-4644, No 36, Simin Alley, Asef Cross, Zaferanieh, Tehran, Iran. Tel. +98 (21) 22413790. Fax. +98 (21) 22409314. E-mail: a_moini{at}royaninstitute.org - Jila Ahmadi, Associated Professor of Obstetric and Gynecology, Department of Endocrinology and Female Infertility, Royan Institute, PO Box 19395-4644, No 36, Simin Alley, Asef Cross, Zaferanieh, Tehran, Iran. Tel. +98 (21) 22413790. Fax. +98 (21) 22409314. E-mail: a_moini{at}royaninstitute.org - Hooman Honar, Associated Professor of Obstetric and Gynecology, Department of Endocrinology and Female Infertility, Royan Institute, PO Box 19395-4644, No 36, Simin Alley, Asef Cross, Zaferanieh, Tehran, Iran. Tel. +98 (21) 22413790. Fax. +98 (21) 22409314. E-mail: a_moini{at}royaninstitute.org - Kiarash Riazi, Associated Professor of Obstetric and Gynecology, Department of Endocrinology and Female Infertility, Royan Institute, PO Box 19395-4644, No 36, Simin Alley, Asef Cross, Zaferanieh, Tehran, Iran. Tel. +98 (21) 22413790. Fax. +98 (21) 22409314. E-mail: a_moini{at}royaninstitute.org Abstract OBJECTIVE: To determine the effect of low-dose aspirin on ovarian response, implantation and pregnancy rates in patients undergoing in-vitro fertilization (IVF) cycles. METHODS: We performed a randomized analysis of 145 infertile women with a mean±SD age of 29.6 ± 4.47 years who underwent cyles of IVF. Patients received 100 mg of aspirin (n=72) or placebo (n=73) daily. This study was conducted in Royan Institute, Tehran, Iran from April 2002 to January 2004. Aspirin was started on the 21st of their preceding menstrual cycle and it was continued until menstruation or a negative pregnancy test. Pregnant women received the medication until 12 weeks of pregnancy. The main outcome measures were number of follicles >/=15mm, number of oocytes retrieved, serum E2 levels, cancellation rate, Ovarian Hyperstimulation Syndrome (OHSS) occurrence, number of embryos transferred, and implantation and pregnancy rates. RESULTS: There were statistically significant differences between the treatment group and the control group in the number of follicles (7.4 ± 4.1 versus 9.0 ± 4.8) and OHSS occurrence (5.6% versus 23.3%) but not in the other measures. CONCLUSION: The addition of aspirin low dose (100 mg/daily) to the standard long protocol for oocyte retrieval did not improve implantation and pregnancy rates in unselected patients undergoing IVF cycles. Article Type Research Article Recommended Citation Moini, Ashraf; Zafarani, Fatemeh; Haddadian, Sedigheh; Ahmadi, Jila; Honar, Hooman; and Riazi, Kiarash (2007) "Effect of low-dose aspirin therapy on implantation rate in women undergoing in-vitro fertilization cycles," Saudi Medical Journal: Vol. 28: Iss. 5, Article 11. DOI: https://doi.org/10.15537/1658-3175.3897 DOWNLOADS Since April 09, 2026 COinS

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