Effect of Low Dose Aspirin Therapy on Pregnancy Rate in Women Undergoing in Vitro Fertilization : A Randomised Controlled Trial

Background: acetylsalicylic acid was synthesized in 1897. The product was called aspirin. In 1971, Vane described the mechanism of action of aspirin and showed that it inhibited the enzyme cyclooxygenase, thus avoiding prostaglandin (PG) synthesis. Aspirin (acetylsalicylic acid) is well known to have analgesic, anti-inflammatory and antipyretic properties. Since aspirin has been shown to increase uterine perfusion, it was not unreasonable to assume that aspirin administration may increase endometrial receptivity and blastocyst implantation. Aim of the work: this study aimed to assess the efficacy of low dose aspirin treatment in increasing the clinical pregnancy in infertile women undergoing IVF /ICSI. Patients and methods: this study included 200 infertile women undergoing IVF/ICSI who recruited from the Infertility Clinic of Ain-Shams University, Maternity Hospital and a Private Center. Results: there was no statistically significant difference between both groups (Aspirin and Placebo) as regard age, cumulus, MII, fertilization rate, grade 1 embryo, grade 2 embryo and total ET. There was statistically non-significant difference between both groups as regard clinical pregnancy. There was statistically non-significant difference between both groups as regard living birth. There was statistically non-significant difference between both groups as regard miscarriage. Conclusion: in the total of 200 women were recruited. The clinical pregnancy rate of the Aspirin group showed no statistically significant difference from that of the placebo group (39% compared to 35%). Recommendations: the use of Aspirin before IVF is not associated with a higher pregnancy rate. Therefore, no need for Aspirin to be added before IVF, However, further studies are needed to confirm our study.