Treatment of Endometriosis and Chronic Pelvic Pain with Letrozole and Norethindrone Acetate

Chawla S; S Chawla; Sonia Chawla

doi:10.1016/s0377-1237(10)80039-5

Treatment of Endometriosis and Chronic Pelvic Pain with Letrozole and Norethindrone Acetate

Chawla S, S Chawla, Sonia Chawla

Medical journal, Armed Forces India · 2010 · vol. 66(3) , pp. 213–215 · doi:10.1016/s0377-1237(10)80039-5 · PMID:27408303 · PMC4921342 · W2033397457

article OA: bronze CC0 ⤵ 7 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated the efficacy of letrozole combined with norethindrone acetate in treating endometriosis and chronic pelvic pain.

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Abstract

BackgroundEndometriosis is encountered in 7-10% of actively menstruating women, with a suspected prevalence as high as 22% in asymptomatic women. It is an important cause of chronic pelvic pain. The aim of this study was to evaluate the efficacy and safety of letrozole in combination with norethindrone acetate and calcium in the management of endometriosis associated pelvic pain.MethodsProspective non-randomized open label study was carried out including 20 patients with endometriosis related pelvic pain that was refractory to previous treatments.ResultIn all 14 patients completed the study. All patients showed significant improvement of pain scores and revealed significant improvement of features of endometriosis on being given letrozole in combination with norethindrone acetate and calcium.ConclusionLetrozole is an effective drug for treatment of endometriosis.

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Condition tags

endometriosischronic_pelvic_pain

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (13)

Cited by (7)

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[2] Add-Back Therapy in the Treatment of Endometriosis Associated Pain via openalex

[3] Anastrazole and oral contraceptives: a novel treatment for endometriosis via openalex

[4] Aromatasehemmer - theoretisches Konzept und bisherige Erfahrungen in der Endometriosetherapie via openalex

[5] Effects of aromatase inhibitors on proliferation and apoptosis in eutopic endometrial cell cultures from patients with endometriosis via openalex

[6] Future Perspectives in the Medical Treatment of Endometriosis via openalex

[7] GnRH analogs: Options for endometriosis-associated pain treatment via openalex

[8] Leuprolide Acetate Depot and Hormonal Add-Back in Endometriosis: A 12-Month Study via openalex

[9] Prolonged gonadotropin-releasing hormone agonist treatment of symptomatic endometriosis: the role of cyclic sodium etidronate and low-dose norethindrone “add-back” therapy via openalex

[10] Role of the vaginally administered aromatase inhibitor anastrozole in women with rectovaginal endometriosis: a pilot study via openalex

[11] Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor via openalex

[12] Treatment of symptomatic rectovaginal endometriosis with an estrogen–progestogen combination versus low-dose norethindrone acetate via openalex

[13] W2412063026 via openalex