Association of FCRL3 C-169T promoter single-nucleotide polymorphism with idiopathic infertility and infertility-related endometriosis
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This study investigated the association between the FCRL3 C-169T promoter single-nucleotide polymorphism and idiopathic infertility and infertility-related endometriosis.
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Abstract
An aberrant immunological mechanism is thought to be involved in the pathogenesis of endometriosis. The present study aimed to determine whether there is a relationship between endometriosis and/or infertility and the FCRL3 C-169T polymorphism. This case-control study included 167 infertile women with endometriosis, 60 women with idiopathic infertility and 167 fertile women. Detection of the FCRL3 C-169T polymorphism was performed using TaqMan PCR. A significant difference in the genotype and allele frequencies of the FCRL3 C-169T polymorphism between endometriosis-related infertility (p=0.003 and p=0.001) and idiopathic infertility (p=0.027 and p=0.0185) versus controls was demonstrated. In conclusion, the results suggest that the FCRL3 C-169T polymorphism may play an important role in the pathogenesis of endometriosis and/or infertility.
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Cited by (10)
- Genetic basis of endometriosis comorbidity 2024
- Association of FCRL3 Genetic Polymorphisms With Endometriosis-Related Infertility Risk 2015
- Understanding the role of epigenomic, genomic and genetic alterations in the development of endometriosis (Review) 2014
- The FCRL3 −169T>C polymorphism and the risk of endometriosis-related infertility in a Polish population 2013
- Polymorphic variants of DNMT3A and the risk of endometriosis 2012
- Insights into Assessing the Genetics of Endometriosis 2012
- Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis 2012
- Association of FCRL3 −169T/C polymorphism with endometriosis and identification of a protective haplotype against the development of the disease in Brazilian population 2011
- 10.1016/j.endend.2011.06.063 2000
- 10.1016/j.endend.2011.08.035 2000
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- europepmc
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- openalex
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- pubmed
- last seen: 2026-05-13T22:16:42.478857+00:00
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