Early-life environmental exposures and the risk of endometriosis/adenomyosis in the NutriNet-Santé cohort

Helene Amazouz, Hélène Amazouz, Solène Gouesbet, Laurent Bourhis, Serge Hercberg, Alice Bellicha, Mathilde Touvier, Marina Kvaskoff
The Science of the total environment · 2025 · vol. 968 , pp. 178790 · doi:10.1016/j.scitotenv.2025.178790 · PMID:39983486 · W4407760418
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This study investigated the association between early-life environmental exposures and the risk of endometriosis/adenomyosis within the NutriNet-Santé cohort.

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Abstract

OBJECTIVE: The etiology of endometriosis is poorly known; established risk factors are limited and few environmental risk factors have been identified. We aimed to explore the associations between several perinatal and childhood environmental exposures and the risk of endometriosis/adenomyosis in women. METHODS: This study was based on NutriNet-Santé, an ongoing web-based prospective cohort following-up several tens of thousands of French adults since 2009. The analysis included 25,251 women with health data available who completed a self-administered questionnaire on perinatal and childhood exposures in 2019. Associations with self-reported endometriosis/adenomyosis were investigated using multivariable logistic regression models, adjusted for potential confounders identified through direct acyclic graphs. RESULTS: Among women, 1126 (4.5 %) self-reported a diagnosis of endometriosis/adenomyosis. Endometriosis/adenomyosis was positively associated with a low birth weight (<2500 g vs. ≥2500 g: adjusted odds-ratio (aOR) = 1.43, 95 % confidence interval (95 % CI) = 1.03-2.00), exposure to maternal smoking during pregnancy (aOR = 1.86, 95 % CI = 1.33-2.61), daycare attendance (aOR = 1.61, 95 % CI = 1.11-2.33), exposure to pets in childhood (both cat and dog vs. no animals: aOR = 1.23, 95 % CI = 1.08-1.41), and mold exposure in housing during childhood (aOR = 1.42, 95 % CI = 1.15-1.74). Conversely, living on a farm during childhood (aOR = 0.77, 95 % CI = 0.62-0.97) and having farmer parents (aOR = 0.72, 95 % CI = 0.54-0.97) were inversely associated with endometriosis. Maternal age at birth, birth length, prematurity, mode of delivery, or exposure to breastfeeding was not associated with endometriosis/adenomyosis. CONCLUSION: Findings from this large population-based study among French adult women suggest associations between several perinatal and childhood exposures and endometriosis/adenomyosis. Research on early-life and childhood environments with endometriosis/adenomyosis might have important implications for the primary prevention of endometriosis and adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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