Use of the Levonorgestrel Intrauterine System in Adolescents with Endometriosis

Jennie Yoost, Yoost J, A. Scott LaJoie, LaJoie AS, Paige Hertweck, Hertweck P, Loveless M, Meredith Loveless
Journal of Pediatric and Adolescent Gynecology · 2013 · vol. 26(2) , pp. 120–124 · doi:10.1016/j.jpag.2012.11.002 · PMID:23518190 · W2059546774
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This study investigated the efficacy and safety of the levonorgestrel intrauterine system in adolescents diagnosed with endometriosis.

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Abstract

Study objectiveThe purpose of this study was to evaluate our adolescent patient population who had received a levonorgestrel intrauterine system (LNG-IUS) at or after the time of endometriosis diagnosis, and determine efficacy of the LNG-IUS in regards to pain and bleeding on follow-up exam.DesignRetrospective cohort study.SettingPediatric Adolescent Gynecology Clinic and Children's Hospital in a metropolitan area.ParticipantsAdolescent patients age 14-22 with pathology-proven endometriosis who had the LNG-IUS placed during the course of their treatment for this disease. Patients were divided into LNG-IUS placement at the time of surgical diagnosis versus placement some time after diagnosis.Main outcome measuresPain and bleeding were assessed by follow-up exam. Pain was classified at each follow-up visit as either none, minimal, moderate, or severe. Bleeding was classified as none, irregular spotting, irregular bleeding, or daily bleeding.ResultsThe majority of patients (67%) required additional hormonal therapy for pain and bleeding suppression. Time to bleeding suppression and pain suppression was sooner in the group with interval time between surgical diagnosis and LNG-IUS placement, compared to LNG-IUS placement at the time of surgery (2.4 months vs 5.3 months until bleeding suppression, and 3.8 months vs 4.8 months until pain suppression), although statistical significance was not achieved.ConclusionsThe LNG-IUS is an option for treatment of endometriosis in adolescents. As pain is the main problem associated with endometriosis, LNG-IUS placement is beneficial at the time of surgery when it is diagnosed. A prospective study is needed for further assessment of outcomes.

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Condition tags

endometriosis

MeSH descriptors

Contraceptive Agents, Female Endometriosis Intrauterine Devices, Medicated Levonorgestrel Adolescent Adult Cohort Studies Combined Modality Therapy Contraceptive Agents, Female Drug Therapy, Combination Endometriosis Endometriosis Female Follow-Up Studies Hemorrhage Hemorrhage Hemorrhage Humans Levonorgestrel Pain

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