Dynamic contrast-enhanced MR imaging to assess physiologic variations of myometrial

Isabelle Thomassin‐Naggara, Daniel Balvay, Émile Daraï, C. Marsault, Marc Bazot, C.A. Cuénod, Hôpital Tenon
2010 · W2547599419
OA: closed CC0 Metadata only
View on OpenAlex
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

Dynamic contrast-enhanced MRI revealed distinct microvascular parameter differences between the inner and outer myometrium, along with menstrual cycle-dependent variations and postmenopausal changes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Purpose: To prospectively evaluate the ability of dynamic con- trast-enhanced magnetic resonance imaging (DCE-MRI) to assess phys- iological microvascular states in nor- mal myometrium. Materials and methods: Eighty-five women (62 women of reproductive age, 23 post- menopausal) undergoing DCE-MRI of the pelvis were included. Micro- vascular parameters for the inner and outer myometrium were analysed using a pharmacokinetic model. These parameters were tissue blood flow (F), blood volume fraction (Vb), permeability-surface area product (PS), interstitial volume fraction (Ve) and lag time (Dt). Results: In the women of reproductive age, the inner myometrium displayed higher F and PS, lower Vb and Ve, and longer Dt than the outer myometrium (p=0.02, p=0.01, p=0.005, p=0.03 and p= 0.01, respectively). The inner myo- metrium presented microvascular variations during the menstrual cycle with a pre-ovulatory peak followed by a fall reaching a nadir of F and Vb about 4 days after ovulation. Com- pared with women of reproductive age, in the postmenopausal state, F and Vb decreased in the outer myo- metrium, while PS, Ve and Dt in- creased (p<0.0001, p=0.001, p= 0.001, p=0.03 and p=0.0004, re- spectively). Conclusion: DCE-MRI is a non-invasive technique that can measure variations of myometrial microcirculation, and thereby be po- tentially useful to help characterize the role and states of the myometrium in assisted reproductive therapy.

My notes (saved in your browser only)

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (59)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK