Buspirone ameliorates premature ovarian insufficiency evoked by cyclophosphamide in female rats; attention to AMPK/Nrf2/HO-1, α-Klotho/NLRP3/Caspase-1, and Caspase-3-mediated apoptosis interplay

Waleed A.I. Khallaf, Ehab E Sharata, Mina Ezzat Attya, Remon Roshdy Rofaeil, Marwa M. Khalaf, Ramadan A.M. Hemeida, Amira M. Abo‐Youssef
In: Toxicology and Applied Pharmacology · 2025 · vol. 500 , pp. 117373 · doi:10.1016/j.taap.2025.117373 · PMID:40345558 · W4410176735
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Buspirone treatment reversed cyclophosphamide-induced premature ovarian insufficiency in rats by modulating AMPK/Nrf2/HO-1, α-Klotho/NLRP3/Caspase-1 pathways and reducing apoptosis.

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