Danazol in the treatment of myelodysplastic syndromes

A C Buzaid, Antônio C. Buzaid, Harinder S. Garewal, H S Garewal, S M Lippman, Scott M. Lippman, B G Durie, Brian G.M. Durie, S B Katakkar, Suresh Katakkar, B R Greenberg, Bernard R. Greenberg
European journal of haematology · 1987 · vol. 39(4) , pp. 346–348 · doi:10.1111/j.1600-0609.1987.tb00780.x · PMID:3319676 · W2034202205
Non-randomised trial OA: closed CC0 ⤵ 15 in-corpus citations
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Danazol treatment of 20 myelodysplastic syndrome patients resulted in short-lived, clinically insignificant platelet count increases in three patients, with no response observed for anemia or leukopenia.

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Abstract

20 patients with myelodysplastic syndromes (MDS) were treated with danazol, 800 mg daily in 4 divided doses. 18 patients were evaluable for response. 3 patients (17%), whose principal problem was anemia, responded to treatment, but only with an increase in platelet count. Responses were short-lived and lacked clinical significance. No patients with anemia or leukopenia responded to treatment and none of the 7 patients with a platelet count less than 30 x 10(9)/l responded. Danazol appears to have limited clinical utility in the treatment of MDS. However, occasional patients with thrombocytopenia may benefit.

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MeSH descriptors

Danazol Myelodysplastic Syndromes Pregnadienes Clinical Trials as Topic Danazol Danazol Female Humans Male Myelodysplastic Syndromes Pregnadienes

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