Efficacy of danazol treatment in infertile patients with endometriosis

A Kulenthran, Kulenthran A
The Medical journal of Malaysia · 1992 · vol. 47(1) , pp. 11–4 · PMID:1387442 · W2290737029
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Danazol treatment for six months yielded a cumulative pregnancy rate of 11% in early-stage endometriosis and 26% in moderate-to-severe stages, challenging the prognostic value of endometriosis staging for fertility.

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Abstract

The study was done to assess the efficacy of danazol in the treatment of infertile patients with all stages of endometriosis. The cumulative pregnancy rates in 21 patients with Stage I and II endometriosis were compared to 21 patients with Stage III and IV endometriosis. Both groups had danazol treatment for six months. All other fertility related factors were controlled for in both groups. There was a cumulative pregnancy rate of 11% (standard error 7%) at 12 months of follow-up in the group with Stage I and II disease whilst it was 26% (standard error 10%) in the group with moderate or severe disease. These results question the validity of any classification system in prognosticating for fertility in patients with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Infertility, Female Adult Adult Danazol Danazol Endometriosis Endometriosis Female Female Humans Humans Infertility, Female Infertility, Female Pregnancy Pregnancy

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (10)

Source provenance

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