Expression of ETS-1 related to angiogenesis in uterine endometrium during the menstrual cycle

Jiro Fujimoto, Ikumi Aoki, Hiroshi Toyoki, Sufia Khatun, Eriko Sato, Teruhiko Tamaya
In: Journal of Biomedical Science · 2003 · vol. 10(3) , pp. 320–327 · doi:10.1007/bf02256451 · PMID:12711859 · W1990724166
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

ETS-1 is localized in uterine endometrium vascular endothelial cells and its expression correlates with microvessel counts and VEGF levels, increasing during the proliferative and peri-ovulatory phases.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This paper investigated whether the ETS-1 transcription factor functions as an angiogenic mediator in human uterine endometrium across the menstrual cycle. Using immunohistochemistry, it found ETS-1 localization that resembled vascular endothelial cells, and reported significant correlations between microvessel counts and both ETS-1 histoscores and ets-1 mRNA levels. ETS-1 expression increased during the proliferative phase, peaked around peri-ovulation, decreased in the secretory phase, and correlated with VEGF levels in the proliferative phase, supporting a link between ETS-1 and VEGF-associated angiogenesis. The main caveat is that the study measures association during cycle phases rather than directly establishing causal mediation. This paper is centrally about endometriosis — it focuses on uterine endometrial angiogenesis regulation by ETS-1 across the menstrual cycle, a mechanism discussed in relation to endometriosis pathophysiology.

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