Expression of HOXA-10 and HOXA-11 in the endometria of women with idiopathic infertility

Małgorzata Szczepańska, Przemysław Wirstlein, Michał W. Łuczak, Paweł P. Jagodzińśki, Jana Skrzypczak
In: Folia Histochemica et Cytobiologica · 2011 · vol. 49(1) , pp. 111–118 · doi:10.5603/fhc.2011.0016 · PMID:21526497 · W2097801121
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This study found decreased HOXA-10 and HOXA-11 mRNA levels but no significant differences in HOXA-10 protein levels in the endometria of women with idiopathic infertility compared to controls.

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Abstract

In fertile women, HOXA-10 and HOXA-11 expression rises during the luteal phase, with the peak occurring during the implantation window, and stays at a high level until the end of the cycle. We evaluated the transcript and protein levels of HOXA-10 and HOXA-11 in the endometria of patients with idiopathic infertility (n = 15) and control patients (n = 10). The amounts of mRNA were determined by reverse transcription and real-time quantitative PCR. The protein levels were evaluated by Western blotting analysis. Using immunohistochemical techniques, we compared the localization of HOXA-10 and HOXA-11 proteins in the implantation window between the study and control groups. We observed statistically significantly decreased HOXA-10 and HOXA-11 transcript levels (p = 0.003, p = 0.012 respectively) in infertile patients compared to controls. There was no significant decrease in HOXA-10 protein levels between these groups (p = 0.074). However, we observed a significantly higher level of HOXA-11 protein in the endometria of infertile patients compared to controls (p = 0.015). HOXA-10 and HOXA-11 proteins were localized in the nuclei of the endometrial stromal cells. Immunohistochemical analyses did not reveal differences between amounts of HOXA-10 and HOXA-11 protein levels in infertility and control groups. Our results suggest that HOXA-10 and HOXA-11 gene expression in the endometrium during the implantation window may not be altered in patients with idiopathic infertility.

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infertility

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