Qualitative and quantitative features of deep endometriosis in contrast-enhanced ultrasound: An initial experience and literature review

Zheng Z, Zijie Zheng, Shen Zhang, Zhang S, Zheng C, Cheng Zheng, Wang R, Ruxue Wang, Zhang Y, Yanping Zhang, Chen P, Peixin Chen, Shanglan Zhou, Zhou S, Luo B, Baoming Luo, Na Di, Di N
Clinical hemorheology and microcirculation · 2023 · vol. 85(1) , pp. 73–82 · doi:10.3233/ch-231843 · PMID:37522202 · W4385341030
Review OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

Contrast-enhanced ultrasound revealed heterogeneous hypo-enhancement and rapid washout in deep endometriosis lesions, suggesting CEUS is a promising non-invasive diagnostic tool.

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Abstract

PURPOSE: This research aims to present the findings of contrast-enhanced ultrasound (CEUS) in a series of patients with proven deep endometriosis (DE) and provide an updated literature review. MATERIALS AND METHODS: Between January 2018 and October 2022, seven patients with DE lesions had their imaging and medical records retrospectively reviewed. Clinical data, recorded images of a standardized conventional B-mode ultrasound, and Sonovue® CEUS were interpreted by two blinded, independent, experienced radiologists in consensus. The enhanced characteristics of the DE lesion on CEUS were also assessed using VueBox® software quantitatively. RESULTS: DE lesion appeared as irregular hypoechoic or heterogeneous on conventional ultrasound with dotted blood flow signal on color Doppler. Six of seven DE lesions showed heterogeneous hypo-enhancement in arterial phases. All the lesions showed a heterogeneous washout rapidly that began in the late arterial phase. In quantified analysis, the mean relative peak enhancement compared with adjacent tissue was 0.47±0.25. CONCLUSION: Our findings and literature review suggested that CEUS could be a feasible and promising non-invasive modality for diagnosing DE.

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Condition tags

endometriosis

MeSH descriptors

Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media Contrast Media

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (3)

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