Oocyte Vitrification for Fertility Preservation in Women with Benign Gynecologic Disease: French Clinical Practice Guidelines Developed by a Modified Delphi Consensus Process

Blandine Courbière, Énora Le Roux, Enora Le Roux, Emmanuelle Mathieu d’Argent, Emmanuelle Mathieu d'Argent, Antoine Torre, Catherine Patrat, Christophe Poncelet, C. Poncelet, Jacques Montagut, Anne-Sophie Gremeau, Anne‐Sophie Grémeau, Hélène Creux, H. Creux, Maëliss Peigné, Isabella Chanavaz-Lacheray, Isabella Chanavaz‐Lacheray, Lara Dirian, Xavier Fritel, Jean‐Luc Pouly, Jean-Luc Pouly, Arnaud Fauconnier, on behalf of the PreFerBe Expert Panel
Journal of clinical medicine · 2021 · vol. 10(17) , pp. 3810 · doi:10.3390/jcm10173810 · PMID:34501257 · PMC8432013 · W3180791917
article OA: gold CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study developed French clinical practice guidelines for oocyte vitrification in women with benign gynecologic disease, reaching consensus on 28 items, including informing women about live birth likelihood by age.

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Abstract

International guidelines are published to provide standardized information and fertility preservation (FP) care for adults and children. The purpose of the study was to conduct a modified Delphi process for generating FP guidelines for BGD. A steering committee identified 42 potential FP practices for BGD. Then 114 key stakeholders were asked to participate in a modified Delphi process via two online survey rounds and a final meeting. Consensus was reached for 28 items. Among them, stakeholders rated age-specific information concerning the risk of diminished ovarian reserve after surgery as important but rejected proposals setting various upper and lower age limits for FP. All women should be informed about the benefit/risk balance of oocyte vitrification-in particular about the likelihood of live birth according to age. FP should not be offered in rASRM stages I and II endometriosis without endometriomas. These guidelines could be useful for gynecologists to identify situations at risk of infertility and to better inform women with BGDs who might need personalized counseling for FP.

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rASRM

Condition tags

endometriosisinfertility

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