Immunohistochemical Estrogen Receptor Assessment in Hyperplastic, Neoplastic, and Physiologic Endometria

Shuhan Huang, S J Huang, Huang SJ, Cheng L, L. L. Cheng, L Cheng, Lewin KJ, K J Lewin, K. Lewin, Fu YS, Yao Fu, Y S Fu
Pathology, research and practice · 1991 · vol. 187(4) , pp. 487–495 · doi:10.1016/s0344-0338(11)80012-9 · PMID:1876529 · W2038241877
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This study examined estrogen receptor expression patterns in hyperplastic, neoplastic, and normal endometrial tissues using immunohistochemistry.

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Abstract

Endometrial hyperplasias and some endometrial carcinomas arise in a setting of estrogen excess. Steroid hormones interact with cells via specific receptors; assessing receptor levels may indicate a tissue's potential for interaction with that hormone. To examine estrogen receptor (ER) levels in endometrial hyperplasia, endometrial carcinoma, and physiologically cycling endometrium, an immunohistochemical technique utilizing a monoclonal anti-estrophilin (estrogen receptor) antibody was applied to formalin-fixed, paraffin-embedded tissue. In complex hyperplasia and grade I adenocarcinoma, the mean percentages of epithelial cells demonstrating nuclear staining for ER was mildly decreased compared to proliferative endometrium. A trend was noted toward less ER staining in atypical hyperplasia compared to non-atypical complex hyperplasia. ER varied with physiologic cycling of the endometrium. ER was also present in atrophic endometrium, myometrium, adenomyosis, and leiomyomata. Immunohistochemistry permits localization of ER and is a useful technique in ER assessment of endometrial hyperplasias and carcinomas.

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MeSH descriptors

Endometrial Hyperplasia Endometrium Receptors, Estrogen Uterine Neoplasms Adenocarcinoma Adenocarcinoma Adult Aged Antibodies, Monoclonal Endometrial Hyperplasia Endometrial Hyperplasia Endometrium Endometrium Female Humans Immunohistochemistry Menstrual Cycle Middle Aged Myometrium Myometrium

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