Abnormal uterine bleeding: etiology and pathogenesis (descriptive review)

E. V. Enkova, Еlena V. Kiseleva, O. V. Khoperskaya, Andrey V. Khatuncev, Inga D. Tyurina
In: RESEARCH RESULTS IN BIOMEDICINE · 2022 · vol. 8(3) · doi:10.18413/2658-6533-2022-8-3-0-8 · W4296286103
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This review describes the complex causes and mechanisms underlying abnormal uterine bleeding, highlighting key factors involved in its pathogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This descriptive review analyzes literature from the last 10 years on abnormal uterine bleeding, focusing on terminology, etiological and pathogenetic mechanisms, and classification systems using sources such as PubMed, eLibrary, and Scopus. It reports that the problem remains highly prioritized in international gynecologic practice and is addressed in international recommendations, and that adopting unified terminology with the FIGO classification helps standardize research and care approaches. The review concludes that FIGO recommends the PALM-COEIN system for classifying non-gestational causes of abnormal uterine bleeding, and it states that the etiologic diagnosis is linked to treatment success; it also notes that understanding pathogenesis could support new diagnostic and monitoring tools, especially for “endometrial” and “unclassified” causes. This paper is centrally about abnormal uterine bleeding etiology and classification, with explicit relevance to endometriosis because it highlights “endometrial” and “unclassified” causes where endometriosis-related bleeding mechanisms may overlap in the differential framework, though it does not specifically analyze endometriosis.

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last seen: 2026-06-10T17:14:06.276822+00:00
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