Extracellular matrix deficiency contributes to irregular uterine bleeding following progestin therapy for adenomyosis†

Ye X, Xiaoye Ye, Jin O, Ou Jin, Aolin Zheng, Zheng A, Lv N, Nengyuan Lv, Jialu Guo, Guo J, Xiang J, Jingjing Xiang, Hao Chen, Chen H, Fengjuan Liu, Liu F, Liu Y, Yuan Liu, Jin C, Chunyu Jin, Wu Y, Yongfeng Wu, Jinyi Tong
Biology of reproduction · 2026 · vol. 115(3) , pp. 750–761 · doi:10.1093/biolre/ioag141 · PMID:42424391 · W7167812862
Lab / animal OA: closed public-domain-us
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-13 ⓘ

Reduced extracellular matrix and collagen levels in adenomyosis endometrium correlate with irregular bleeding during progestin therapy, suggesting matrix metalloproteinase inhibition or collagen supplementation as potential preventative treatments.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Adenomyosis is a common gynecological disorder that causes heavy menstrual bleeding and chronic pelvic pain. Progestin-based therapy is widely used for long-term management, but irregular uterine bleeding frequently occurs and severely affects patients' quality of life. The mechanisms underlying this side effect remain unclear. In this study, we performed proteomic sequencing on endometrial tissues from adenomyosis patients before progestin treatment. We found that patients who later developed irregular bleeding exhibited significantly reduced extracellular matrix and collagen levels. Cell experiments showed that matrix metalloproteinase inhibition increased collagen expression in patient-derived endometrial stromal cells. In a mouse model of progestin-induced uterine bleeding, both matrix metalloproteinase inhibition and intrauterine collagen supplementation effectively reduced bleeding. These findings indicate that insufficient extracellular matrix predisposes patients to bleeding during progestin therapy and provide potential strategies to prevent progestin-related irregular bleeding.

My notes (saved in your browser only)

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (24)

SciLite annotations

chemicals 6
progestin progestin progestin progestin progestin progestin
organisms 1
transgenic mice

Source provenance

europepmc
last seen: 2026-10-10T06:11:15.153948+00:00
openalex
last seen: 2026-10-07T06:01:52.021920+00:00
pubmed
last seen: 2026-10-10T06:03:13.489758+00:00
scilite
last seen: 2026-08-02T09:40:10.667495+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine