Expression of metalloproteinase-9 in ectopic endometrium in women with endometriosis

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This study found that ectopic endometrium in women with endometriosis exhibits higher levels of matrix metalloproteinase-9 (MMP-9) than eutopic endometrium, with expression increasing as endometriosis progresses.

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Abstract

OBJECTIVE: To study the expression of matrix metalloproteinase-9 (MMP-9) in ectopic and eutopic endometrium from women with endometriosis, thereby to determine the role of matrix metalloproteinases in the pathogenesis of endometriosis. METHODS: Both ectopic and eutopic endometrium tissue specimens were obtained from 30 women with endometriosis, and gelatinase activity in the specimens was detected by zymography and quantitated by Gel Documentation Analysis System. RESULTS: MMP-9 was detected in both eutopic and ectopic endometrium, but the latter contained higher levels of MMP-9 than the former did, and as the endometriosis worsened, MMP-9 expression tended to increase further. CONCLUSION: Endometriotic tissue possesses higher level of gelatinase activity than eutopic endometrium from patients with endometriosis does, and MMP-9 might be of importance for the implantation and invasive growth of endometriotic tissue that may lead to endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Matrix Metalloproteinase 9 Electrophoresis, Polyacrylamide Gel Electrophoresis, Polyacrylamide Gel Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Humans Humans Matrix Metalloproteinase 9 Matrix Metalloproteinase 9

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (14)

Source provenance

europepmc
last seen: 2026-10-18T09:30:06.152893+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:00:45.472718+00:00
License: CC0 · commercial use OK