Dapsone hydroxylamine-mediated alterations in human red blood cells from endometriotic patients

Alessandra Andrisani, Donà G, Gabriella Donà, Chiara Sabbadin, Stefano Dall’Acqua, Stefano Dall'Acqua, Elena Tibaldi, Tibaldi E, Antonella Roveri, Valentina Bosello Travain, Anna Maria Brunati, Ambrosini G, Guido Ambrosini, Eugenio Ragazzi, Armanini D, Decio Armanini, Luciana Bordin
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2017 · vol. 33(12) , pp. 928–932 · doi:10.1080/09513590.2017.1332177 · PMID:28557604 · W2618420054
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This study found that dapsone hydroxylamine exacerbates oxidative alterations in red blood cells from endometriotic patients, increasing band 3 tyrosine phosphorylation, high molecular weight aggregates, and carbonic anhydrase activity.

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Abstract

Endometriosis, an estrogen-dependent chronic gynecological disease in women of reproductive age, is characterized by a systemic inflammation status involving also red blood cells (RBCs). In this study, we evaluated how the protein oxidative status could be involved in the worsening of RBC conditions due to dapsone intake in endometriotic women in potential treatment for skin or infection diseases. Blood samples from two groups of volunteers, control group (CG) and endometriosis patient group (PG), were analyzed for their content of band 3 tyrosine phosphorylation (Tyr-P) and high molecular weight aggregate (HMWA) in membranes, and glutathione (GSH) content and carbonic anhydrase (CA) activity in cytosol. In endometriotic patients, RBC showed the highest level of oxidative-related alterations both in membrane and cytosol. More interestingly, the addition of dapsone hydroxylamine (DDS-NHOH) could induce further increase of both membranes and cytosol markers, with an enhancement of CA activity reaching about 66% of the total cell enzyme amount. In conclusion, in PG the systemic inflammatory status leads to the inability of counteracting adjunctive oxidative stress, with a potential involvement of CA-related pathologies, such as glaucoma. Hence, the importance of the evaluation of therapeutic approaches worsening oxidative imbalance present in PG RBC is underlined.

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Condition tags

endometriosis

MeSH descriptors

Dapsone Endometriosis Erythrocytes Oxidative Stress Adult Adult Carbonic Anhydrases Carbonic Anhydrases Carbonic Anhydrases Dapsone Dapsone Dapsone Endometriosis Endometriosis Erythrocytes Erythrocytes Erythrocytes Female Female Humans

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