Editorial: Molecular and cytogenetic research advances in human reproduction.

Bukhari I, Thorne RF, Shi Q
Frontiers in endocrinology · 2022 · doi:10.3389/fendo.2022.1107903 · PMID:36568095 · PMC9780652
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This editorial highlights how next-generation sequencing advances human reproduction research, covering gene roles and infertility treatments like isolating testicular cells in Klinefelter syndrome.

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This editorial discusses how next-generation sequencing technologies have shifted the paradigm in investigating human reproductive disorders by enabling cost-effective, genome-wide data generation. It highlights specific research topics within the field, such as the roles of various genes and hormones, and notes that isolating normal testicular cells from patients with Klinefelter syndrome represents a promising but premature step toward developing infertility cures. The paper serves as an overview of recent molecular and cytogenetic advances rather than presenting original experimental data on specific pathologies. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Conclusions

Recent advances in next-generation sequencing (NGS) technologies have brought a paradigm shift in investigating rare and common human disorders. The ability cost-effectively to generate genome-wide sequencing data with in-depth coverage in a short time frame is replacing approaches that focus on specific regions for gene discovery and clinical testing. Articles included in the current research topic enlighten us about various aspects of human reproduction, such as the roles of different genes, hormones, and technologies. Isolation of normal testicular cells from Klinefelter syndrome could bring the hope of conceiving a child. However, it is too early to predict, but it is an essential step toward developing infertility cures.

Author Contributions

All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.

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