{"paper_id":"b3e1cbea-2d2f-4ad5-a6e1-aa6b5e4df7d2","body_text":"Recent advances in next-generation sequencing (NGS) technologies have brought a paradigm shift in investigating rare and common human disorders. The ability cost-effectively to generate genome-wide sequencing data with in-depth coverage in a short time frame is replacing approaches that focus on specific regions for gene discovery and clinical testing. Articles included in the current research topic enlighten us about various aspects of human reproduction, such as the roles of different genes, hormones, and technologies. Isolation of normal testicular cells from Klinefelter syndrome could bring the hope of conceiving a child. However, it is too early to predict, but it is an essential step toward developing infertility cures.\n\nAll authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.","source_license":"CC-BY-4.0","license_restricted":false}