Prolactin production by human endometrium during the normal menstrual cycle
article
OA: closed
CC0
⤵ 18 in-corpus citations
AI-generated summary
Human endometrium produces prolactin throughout the normal menstrual cycle, with the highest levels observed during the luteal phase.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Prolactin (PRL) synthesis by human decidua from term pregnancies has been reported. The present study examined the tissue content and in vitro production of prolactin by "decidualized" and "nondecidualized" endometrium unassociated with pregnancy. Tissue obtained throughout the menstrual cycle was dated histologically. When proliferative endometrium (N = 16) or secretory endometrium prior to day 22 (N = 6) was examined, no PRL was detected in the tissue or medium after a 24-hour incubation at 37 degrees C in Gey's buffer. Total PRL in tissue and medium measured by radioimmunoassay increased significantly from 1.2 +/- 0.3 ng/100 mg of tissue at cycle days 22 to 24 (N = 4) to 5.3 +/- 2.4 ng/100 mg of tissue at cycle days 25 to 26 (N = 7). The addition of 100 micrograms/ml of cycloheximide to the medium prevented the net increase in PRL content during incubation. It is concluded that PRL is synthesized by endometrium during the normal menstrual cycle and that the appearance and degree of synthesis and decidualization of the stroma correspond.
My notes (saved in your browser only)
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (12)
- Dating the Endometrial Biopsy via openalex
- W110171974 via openalex
- W2025485968 via openalex
- W2072655623 via openalex
- W2119850496 via openalex
- W2399709201 via openalex
- W2413961794 via openalex
- W2416728194 via openalex
- W2418893071 via openalex
- W2923359193 via openalex
- W45837951 via openalex
- W6601926759 via openalex
Cited by (18)
- Bromocriptine inhibits proliferation in the endometrium from women with adenomyosis 2023
- MiR-543 Inhibits the Migration and Epithelial-To-Mesenchymal Transition of TGF-β-Treated Endometrial Stromal Cells via the MAPK and Wnt/β-Catenin Signaling Pathways 2021
- Characteristics of the endometrium in menstruating species: lessons learned from the animal kingdom† 2020
- Regulatory Action of Calcium Ion on Cyclic AMP-Enhanced Expression of Implantation-Related Factors in Human Endometrial Cells 2015
- Regulation of decidualization in human endometrial stromal cells through exchange protein directly activated by cyclic AMP (Epac) 2013
- Effects of metoclopramide-induced hyperprolactinemia on the prolactin receptor of murine endometrium 2009
- NK Cells and Pregnancy 2007
- Progesterone-dependent release of transforming growth factor-beta1 from epithelial cells enhances the endometrial decidualization by turning on the Smad signalling in stromal cells 2005
- Changes in vascular endothelial growth factor production associated with decidualization by human endometrial stromal cells <i>in vitro</i> 2004
- Prolactin receptor in human endometriotic tissues 2002
- Prolactin receptor in human endometriotic tissues 2002
- Modulation of prolactin secretion in human myometrium by cytokines 1994
- Immunohistochemical markers of uterine receptivity in the human endometrium 1993
- Prolactin production by explants of normal, luteal phase defective, and corrected luteal phase defective late secretory endometrium 1985
- Peritoneal fluid prolactin in infertile women with endometriosis: lack of evidence of secretory activity by endometrial implants 1984
- Prolactin secretion by human chorion-decidua in vitro: Influences of mode of delivery and agents that modify prostaglandin synthesis 1983
- Prolactin production during in vitro decidualization of proliferative endometrium 1983
- Evidence that Chorion-Decidual Prolactin Release Is Calcium Dependent* 1982
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0
· commercial use OK