Clear cell carcinoma of the ovary: light and electron microscopic studies

Kiyoshi Ohkawa, Ohkawa K, K Ohkawa, Amasaki H, H Amasaki, Hirofumi Amasaki, Y Terashima, Terashima Y, Yoshiteru Terashima, S Aizawa, Shigeo Aizawa, Aizawa S, Eisei Ishikawa, Ishikawa E, E Ishikawa
Cancer · 1977 · doi:10.1002/1097-0142(197712)40:6<3019::aid-cncr2820400639>3.0.co;2-m · PMID:589565
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This study characterized ovarian clear cell carcinoma microscopically, finding similarities to Arias-Stella endometrium and endocervical clear cell carcinoma, and noted a connection to endometriosis in five cases.

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Abstract

Twelve cases of ovarian clear cell carcinoma were studied histologically. Four cases were examined electron microscopically and compared with other conditions. Five tumors were directly connected with ovarian endometriosis. They were histologically classified into a tubular type with hobnail cells and a solid type without tubular pattern or hobnail cells. Electron microscopic figures of the tumor cells are identical having large nuclei, abundant glycogen, lamellated RER, few lipid droplets, and sparse but well-developed microvilli. The basophilic dark cells frequently encountered in the tubular type are morphologically quite similar to clear cells excepting for sparsity of glycogen and lipid droplets. Alveolar arrangement of 6 to 10 tubular structures (honeycomb structure) resembling alveolate structure seen in late secretory endometrium was found in tumor cells of one case. Ultrastructural feature of clear cell carcinoma closely resemble those of Arias-Stella endometrium and clear cell carcinoma of endocervix suggesting their Muellerian origin.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Ovarian Neoplasms Adenocarcinoma Adenocarcinoma Adult Endometriosis Endometriosis Endometrium Endometrium Female Glycogen Glycogen Humans Kidney Neoplasms Kidney Neoplasms Mesonephroma Mesonephroma Microscopy, Electron Middle Aged Neoplasms, Multiple Primary

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (21)

Source provenance

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