CA 125 and other tumor markers in uterine leiomyomas and their association with lesion characteristics.

Ali Babacan, Cem Kizilaslan, Cem Kızılaslan, Ismet Gun, İsmet Gün, Murat Muhcu, Murat Muhçu, Ercument Mungen, Ercüment Müngen, Vedat Atay
International journal of clinical and experimental medicine · 2014 · vol. 7(4) , pp. 1078–83 · PMID:24955185 · W56689114
article OA: green CC0 ⤵ 7 in-corpus citations
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This study found that CA 125 levels in uterine leiomyoma patients were significantly elevated with larger myoma size and the presence of adenomyosis.

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Abstract

The aim of this study was to investigate the factors associated with serum levels of several tumor markers in a group of patients operated for uterine myoma. One hundred thirty-seven female patients operated for uterine myoma were included. Serum samples were examined for CA 125, CA 19-9, CA 15-3, carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) levels as part of routine workup. Pathological and morphological characteristics of the patients were retrieved from medical records. The mean age was 46.7 ± 8.8 years (range, 22-85 y). Abnormally high levels of CA 125, CA 19-9, CA 15-3, CEA, and AFP were found in 19.7%, 6.6%, 5.1%, 3.7%, and 1.5% of the patients, respectively. Patients with additional adenomyosis and patients with at least one large myoma (≥ 5 cm diameter) had significantly higher levels of CA 125. Multivariate analysis identified coexistence of adenomyosis (OR 7.7 [95% CI, 2.6-23.0], p < 0.001) and presence of at least one large myoma (OR 5.6 [1.4-22.8], p = 0.016) as independent predictors of abnormally high CA 125 levels. CA 125 levels are affected by the tumor size and coexistence of adenomyosis in uterine leiomyomas. Indirect mechanisms caused by large myoma size such as peritoneal irritation may be responsible for CA 125 elevations.

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adenomyosis

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