Serum CA 125 concentrations in women with endometriosis or uterine fibroids treated with gonadotrophin-releasing hormone agonist analogues.

van der Spuy ZM, Z M van der Spuy, Zephne M. van der Spuy, M Wood, Wood M, M.J.A. Wood, Fieggen G, G Fieggen, Graham Fieggen, M. S. Hendricks, Hendricks MS
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 1993 · vol. 83(7) , pp. 510–3 · PMID:8211493 · W2410544201
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Serum CA 125 fell during GnRH agonist treatment in endometriosis patients, reflecting therapeutic progress and potentially obviating surgical follow-up, but did not correlate with uterine fibroid shrinkage.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

The study assessed whether serum CA 125 could be used to monitor gonadotrophin-releasing hormone (GnRH) agonist analogue therapy in women with endometriosis or uterine fibroids. Across participants, serum CA 125 did not correlate with uterine volume and was not useful for assessing shrinkage of uterine fibroids during treatment; however, CA 125 levels fell during treatment in all patients, even though levels were not always elevated at baseline in those with endometriosis. The authors report that the change in CA 125 reflected therapeutic progress, particularly for patients who started therapy with elevated CA 125, while noting limitations related to its lack of utility for fibroid shrinkage assessment. This paper is centrally about endometriosis—specifically, evaluating serum CA 125 as a monitoring marker during GnRH agonist treatment in women with endometriosis.

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Abstract

We assessed the possible role of CA 125 in the monitoring of gonadotrophin-releasing hormone (GnRH) agonist analogue therapy in women with endometriosis and uterine fibroids. Serum concentrations of this cell surface antigen did not correlate with uterine volume and appeared to have no value in the assessment of shrinkage of uterine fibroids during GnRH agonist treatment. While CA 125 levels were not always elevated in subjects with endometriosis, they fell during treatment in all patients. The change accurately reflected therapeutic progress in these women and was of particular value in those patients who had commenced therapy with elevated levels. It is suggested that CA 125 may be useful in the monitoring of therapeutic progress in selected patients with endometriosis treated with GnRH agonists; the need for surgical follow-up may be obviated.
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Abstract

We assessed the possible role of CA 125 in the monitoring of gonadotrophin-releasing hormone (GnRH) agonist analogue therapy in women with endometriosis and uterine fibroids. Serum concentrations of this cell surface antigen did not correlate with uterine volume and appeared to have no value in the assessment of shrinkage of uterine fibroids during GnRH agonist treatment. While CA 125 levels were not always elevated in subjects with endometriosis, they fell during treatment in all patients. The change accurately reflected therapeutic progress in these women and was of particular value in those patients who had commenced therapy with elevated levels. It is suggested that CA 125 may be useful in the monitoring of therapeutic progress in selected patients with endometriosis treated with GnRH agonists; the need for surgical follow-up may be obviated. Description

Keywords

Reference: van der Spuy, Z.M., Wood, M., Fieggen, G. & Hendricks, M. 1993. Serum CA 125 concentrations in women with endometriosis or uterine fibroids treated with gonadotrophin-releasing hormone agonist analogues. South African Medical Journal. 83(7):510 - 513. http://hdl.handle.net/11427/34841

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Condition tags

endometriosis

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Endometriosis Gonadotropin-Releasing Hormone Leiomyoma Uterine Neoplasms Antigens, Tumor-Associated, Carbohydrate Endometriosis Endometriosis Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Humans Leiomyoma Leiomyoma Uterine Neoplasms Uterine Neoplasms

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