Bleeding patterns of women with heavy menstrual bleeding or dysmenorrhoea using the levonorgestrel-releasing intrauterine system: results from a real-world observational study in Japan (J-MIRAI)

Jo Kitawaki, Shigeo Akira, Tasuku Harada, Nagamasa Maeda, Mikio Momoeda, Ikuko Ota, Taku Murakami, Toshiyuki Sunaya, Kazufumi Hirano
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2022 · vol. 27(4) , pp. 300–307 · doi:10.1080/13625187.2022.2067329 · PMID:35611632 · W4281492982
article OA: hybrid CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

The J-MIRAI study found that Japanese women with heavy menstrual bleeding or dysmenorrhoea experienced significant reductions in blood loss and improved quality of life after 12 months of using the levonorgestrel-releasing intrauterine system.

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Abstract

PURPOSE: To collect real-world safety and clinical outcome data on the levonorgestrel-releasing intrauterine system (LNG-IUS) for functional/organic heavy menstrual bleeding (HMB) and dysmenorrhoea in Japanese women (J-MIRAI). MATERIALS AND METHODS: In this prospective, multicentre, single-cohort, open-label, post-authorisation study, we assessed menstrual blood loss after LNG-IUS insertion by changes from baseline in pictorial blood loss assessment chart (PBAC) scores. Scores for the menorrhagia multi-attribute scale (MMAS) were collected for 12 months to assess quality of life. RESULTS: We included 47 patients with complete PBAC score and patient diary data. The median PBAC score before LNG-IUS insertion was 159.0, which decreased significantly to 6.0 at 12 months post-insertion; for patients with adenomyosis (n = 20), PBAC score decreased from 174.5 pre-insertion to 19.5 at 12 months. The number of patient-reported bleeding days was correlated with PBAC score ≥5. The proportion of women with prolonged bleeding decreased from 85.7% to 34.6% by the study's end. Some women reported no bleeding after the first 90-day reference period. The mean MMAS overall score significantly increased from 50.50 before insertion to 88.67 at 12 months. CONCLUSIONS: Japanese women with functional/organic HMB experienced substantial reductions in bleeding symptoms and improvements in quality of life after 12-month use of the LNG-IUS.

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Condition tags

dysmenorrheaadenomyosis

MeSH descriptors

Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female

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europepmc
last seen: 2026-06-23T06:15:44.889181+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-06-23T06:15:40.148923+00:00
License: CC0 · commercial use OK