Impact of pelvic endometriosis on the chances of pregnancy in the context of oocyte donation
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This study investigated the relationship between pelvic endometriosis and pregnancy outcomes in women undergoing oocyte donation.
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Abstract
BACKGROUND: Endometriosis is diagnosed in 25% to 40% of infertile patients. This disease can affect ovarian reserve and oocyte quality, as a result Assisted Reproductive Technology is often required. However, the influence of endometriosis on implantation rates remains debated. Here, we assessed its impact on the chances of pregnancy following oocyte donation.
MATERIAL AND METHODS: A single-center retrospective study was conducted at the Picardie Center for the Study and Conservation of Oocytes and Sperm (CECOS de Picardie), Amiens CHU. Patients who received a fresh embryo transfer after from donated oocytes between January 2011 and December 2021 were included. Two groups were defined according to the presence or absence of endometriosis. All patients in the endometriosis group had stage III-IV disease, confirmed surgically or radiologically RESULTS: In total, 175 patients were included, 34 in the endometriosis group and 141 in the control group. Pregnancy rates were comparable between the two groups (29% vs. 37%, p = 0.43) and there were no significant differences in terms of pregnancy outcomes or obstetrical complications (20% vs. 27%, p = 1).
CONCLUSION: In recipients of donated oocytes, advanced-stage endometriosis does not appear to negatively affect implantation or pregnancy outcomes. These findings support the hypothesis that reduced fertility in endometriosis is primarily related to oocyte quality rather than impaired endometrial receptivity.
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- europepmc
- last seen: 2026-06-13T06:22:48.782012+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-06-13T06:18:54.565665+00:00
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