Composite Tumor Consisting of Dermatofibrosarcoma Protuberans and Giant Cell Fibroblastoma Associated with Intratumoral Endometriosis

Kholová I, I Kholová, Ivana Kholová, Aleš Ryška, A Ryska, K Dědič, K Dedic, Dedic K
Pathology, research and practice · 2001 · vol. 197(4) , pp. 263–267 · doi:10.1078/0344-0338-00045 · PMID:11358013 · W1970431398
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This case report describes a rare composite tumor containing dermatofibrosarcoma protuberans and giant cell fibroblastoma, which was incidentally found to be associated with intratumoral endometriosis.

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Abstract

We present a unique case of composite skin tumor of the vulva consisting of dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) with an intratumoral focus of endometriosis. A 31-year-old female with a 10-year-history of a recurring subcutaneous tumor in the vulvar area underwent excision of the seventh recurrence of the tumor. Microscopic examination revealed a composite fibrohistiocytic tumor consisting of DFSP and GCF. Additionally, a focus of endometriosis within the tumor tissue was found. Malignant transformation of extragonadal endometriosis has already been described; we present, however, the occurrence of a focus of endometriosis within the tissue of a hormonally independent soft tissue tumor. There is a possible link to the occurrence of cutaneous endometriosis at previous surgery sites and in the scars. The presence of endometriosis within the soft tissue tumor represents, to the best of our knowledge, a previously undescribed collision phenomenon.

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Condition tags

endometriosis

MeSH descriptors

Dermatofibrosarcoma Endometriosis Fibroma Giant Cell Tumors Neoplasms, Multiple Primary Soft Tissue Neoplasms Adult Antigens, Neoplasm Antigens, Neoplasm Biomarkers, Tumor Biomarkers, Tumor Dermatofibrosarcoma Dermatofibrosarcoma Dermatofibrosarcoma Endometriosis Endometriosis Endometriosis Female Fibroma Fibroma

Citation neighborhood

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References (31)

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