CLINICAL EXPERIENCE WITH PROVEST IN MANAGEMENT OF ADOLESCENT MENSTRUAL DISORDERS.

The efficacy of therapeutic doses of Provest (10 mg medroxyprogesterone acetate .05 mg ethinyl estradiol) in controlling adolescent menstrual disorders was evaluated in 19 girls. Treatment for 3-6 months satisfactorily prevented amenorrhea-menorrhagia syndrome in 3 of 4 patients and regular ovulatory cycles were soon establishedy Normal menstruation returned in all patients treated for hypermenorrhea and the accompanying anemia disappeared. Mittelschmerz was relieved in all 5 patients during treatment although ovulation pain recurred in 2 patients after treatment was stopped. 3 of 7 patients with severe dysmenorrhea enjoyed permanent relief after the discontinuation of therapy. Treatment of mastodynia was successful in all 4 subjects. 5 cases of acne vulgaris were cleared up by the therapy. The drug was considered to be effective in managing a variety of disorders common to adolescent girls.