CORRELATIONS BETWEEN THE LYMPHOID INFILTRATE AND THE STEROID HORMONE RECEPTORS IN ENDOMETRIOSIS

Ioana Păvăleanu
In: Revista Medico-Chirurgicala · 2023 · vol. 127(3) , pp. 415–424 · doi:10.22551/msj.2023.03.11 · W4388131211
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This study investigated correlations between CD4+, CD8+, and CD68+ immune cell infiltrates and steroid hormone receptor expressions (ER and PR) in endometriosis tissue.

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Abstract

Aim: Endometriosis, a chronic estrogen-dependent disease, is associated with persistent pelvic pain and is classified as a neuro-inflammatory disorder.This study aimed to decipher the inflammatory milieu in endometriosis, focusing on the lymphoid infiltrate represented by the CD4+ cells, CD8+ cells, and CD68+ macrophages, and the possible correlation with steroid hormone receptor expressions.Material and methods: Research conducted at the "Elena Doamna" Clinical Hospital and the "Grigore T. Popa" University of Medicine and Pharmacy in Iai, Romania, involved retrospe ctive analysis of 53 patients with endometriosis from 2018 to 2023.Results: Through immunohistochemical assays, we observed correlations between CD4 and CD8 expressions, and b etween CD4, CD68, and the PR score.Also, a possible causality between the macrophage infi ltrate and PR expression could be suggested.Conclusions: The inflammatory infiltrate's analysis in endometriosis provides a deeper knowledge of its pathological development and the interplay of inflammatory cells.Understanding these receptors might guide future treatment strategies for better disease management.

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endometriosis

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