Endometriosis Peritoneal Fluid Factors Involved in the Alteration of Decidualization Process

Nelly Manolova, Soren Hayrabedyan, Krassimira Todorova, Diana Zasheva, Milena Mourjeva, Stanimir Kyurkchiev, Maria Stamenova
In: Biotechnology & Biotechnological Equipment · 2013 · vol. 27(4) , pp. 3982–3986 · doi:10.5504/bbeq.2013.0032 · W2114444594
Lab / animal OA: bronze CC0
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Endometriotic peritoneal fluid inhibited human endometrial stromal cell decidualization, and proteomic analysis identified Toll-like receptor, NFkB cascade, and cell surface receptor linked signal transduction pathways as significantly contributing to endometriosis pathogenesis.

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Abstract

Endometriosis is accompanied by local and systemic proinflammatory dysregulation, which motivated us to screen for specific marker molecules of the endometriotic peritoneal fluid. Endometriosis affects up to 10 % of the women of reproductive age and is frequently associated with infertility. In the present study we analyzed the influence of endometriotic peritoneal fluid on the decidualization process, by measuring the Prolactin secretion. Since we found that endometriotic peritoneal fluid inhibits human endometrial stromal cells decidualization, we applied two-dimensional polyacrylamide gel electrophoresis in order to compare the proteomic profiles of endometriotic vs. non-endometriotic peritoneal fluids and to identify the most significant protein spots associated with the endometriosis condition. We used 2D DIGE densitometry analysis followed by bioinformatics gene ontology enrichment of the putative proteins corresponding to the identified protein gel spots. Statistically significant pathway identification analysis was performed to pinpoint the most likely key pathways that the putative proteins would be involved in. The obtained results indicated the Toll-like receptor pathway, NFkB cascade pathway, and Cell surface receptor linked signal transduction pathways, as most significantly contributing to the pathogenesis of endometriosis.

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Condition tags

endometriosisinfertility

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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