Assessment of the rehabilitation programs effectiveness in patients with painful external genital endometriosis

E. Begovich, B. Baigalmaa, А. Е. Солопова, В. О. Бицадзе, E. A. Son, G. К. Bykovshchenko
In: Vrach · 2024 · vol. 34(4) , pp. 35–39 · doi:10.29296/25877305-2023-04-07 · W4396823173
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

An active rehabilitation program after radical treatment for painful external genital endometriosis significantly improved patient quality of life and reduced biomarkers compared to passive rehabilitation.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This randomized prospective comparative study evaluated a 12-month “active” comprehensive, personalized rehabilitation program versus “passive” rehabilitation per national clinical recommendations in 104 reproductive-age women with painful external genital endometriosis after radical surgery, assessing objective outcomes at multiple time points up to 12 months (serum CA-125, CA-19.9, IL-6, TNF-α, Femoflor-16 vaginal microbiome measures, vaginal pH, and imaging with ultrasound and MRI). Compared with the passive group, the active group showed significantly greater decreases in these serum biomarkers, better normalization of the urogenital tract microbiocenosis, and more favorable vaginal pH shifts, along with more pronounced improvement in postoperative recovery and pelvic organ/structure status on follow-up assessments. A key caveat stated by the authors is that microbiome testing (Femoflor-16) was not included in the public insurance (OMS) program and therefore was performed in the passive group only at baseline and at 12 months. This paper is centrally about endometriosis — it directly studies rehabilitation effectiveness in women with painful external genital endometriosis after radical treatment.

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Abstract

In patients with a painful form of external genital endometriosis (EGE), the prevailing symptom is chronic pelvic pain, which significantly reduces the quality of life (QoL). It causes disorders of the physical, psycho-emotional and sexual health of women of reproductive age, leading to distress, maladaptation, anxiety-depressive disorders, disruption of social functioning and family relationships. Objective. To evaluate the effectiveness of the rehabilitation program for women with a painful form of EGE after radical treatment in the rehabilitation period. Materials and methods. In the examined cohort were included a total of 104 patients of reproductive age 42.4±3.7 years with a painful form of EGE after radical treatment: Group 1 – 49 women with "active" rehabilitation; Group 2 – 55 patients with "passive" rehabilitation tactics in accordance with standards and National Clinical Guidelines. Integral assessment of QoL (objective) was performed using clinical, laboratory (cancer antigen-125 (CA-125), cancer antigen-19.9 (CA-19.9), interleukin-6 (IL-6), tumor necrosis factor (TNF), femoflor – 16, pH-metric titration), and instrumental studies (ultrasound, magnetic resonance imaging (MRI)). At the control points: before, in 5–9 days, 1,3,6 and 12 months after surgical treatment. Results. Patients with "active" rehabilitation tactics (Group 1) had a significantly more pronounced decrease in the levels of the assessed biomarkers in blood serum, normalization of the urogenital tract microbiocenosis and restoration of pelvic organs and structures, unlike patients in the comparison group. Conclusion. The use of comprehensive personalized rehabilitation in patients with painful form of EGE after radical treatment has demonstrated its effectiveness. Widespread introduction of rehabilitation programs into routine clinical practice is necessary.

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Condition tags

endometriosischronic_pelvic_pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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