The nuclear factor- B pathway is involved in matrix metalloproteinase-9 expression in RU486-induced endometrium breakdown in mice

Yunsong Li, Xiaojuan Xu, Xudong Chen, Wei Guo, G. Wei, Bin He, J.-D. Wang
In: Human Reproduction · 2012 · vol. 27(7) , pp. 2096–2106 · doi:10.1093/humrep/des110 · W2101831504
article OA: bronze CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study investigated the role of the NF-kB pathway in RU486-induced endometrium breakdown in mice, revealing its involvement in matrix metalloproteinase-9 expression during this process.

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Abstract

background: Progesterone-withdrawal (WP)-induced endometrial breakdown occurs in both physiological and pathological processes such as menstruation and abortion. However, the underlying mechanisms are not clearly understood. As the nuclear factor-kB (NF-kB) pathway has been proposed to play a role in endometrial breakdown, we tested this hypothesis using RU486-induced mouse menstruation-like model.

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